Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2010-8-3
pubmed:abstractText
Infection usually leads to the development of acquired immune responses associated with clearance or control of the infecting organism. However, if not adequately regulated, immune-mediated pathology can result. Tuberculosis is a worldwide threat, and development of an effective vaccine requires that the protective immune response to Mycobacterium tuberculosis (Mtb) be dissected from the pathological immune response. This distinction is particularly important if new vaccines are to be delivered to Mtb-exposed individuals, as repeated antigenic exposure can lead to pathological complications. Using a model wherein mice are vaccinated with bacille Calmette-Guérin after Mtb infection, we show that repeated vaccination results in increased IL-17, tumor necrosis factor, IL-6, and MIP-2 expression, influx of granulocytes/neutrophils, and lung tissue damage. This pathological response is abrogated in mice deficient in the gene encoding IL-23p19 or in the presence of IL-17-blocking antibody. This finding that repeated exposure to mycobacterial antigen promotes enhanced IL-17-dependent pathological consequences has important implications for the design of effective vaccines against Mtb.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/20624887-10517722, http://linkedlifedata.com/resource/pubmed/commentcorrection/20624887-10678993, http://linkedlifedata.com/resource/pubmed/commentcorrection/20624887-11895976, http://linkedlifedata.com/resource/pubmed/commentcorrection/20624887-12654841, http://linkedlifedata.com/resource/pubmed/commentcorrection/20624887-12707345, http://linkedlifedata.com/resource/pubmed/commentcorrection/20624887-15032590, http://linkedlifedata.com/resource/pubmed/commentcorrection/20624887-15485625, http://linkedlifedata.com/resource/pubmed/commentcorrection/20624887-15731075, http://linkedlifedata.com/resource/pubmed/commentcorrection/20624887-15780986, http://linkedlifedata.com/resource/pubmed/commentcorrection/20624887-16002675, http://linkedlifedata.com/resource/pubmed/commentcorrection/20624887-16546542, http://linkedlifedata.com/resource/pubmed/commentcorrection/20624887-16790804, http://linkedlifedata.com/resource/pubmed/commentcorrection/20624887-16849446, http://linkedlifedata.com/resource/pubmed/commentcorrection/20624887-17339477, http://linkedlifedata.com/resource/pubmed/commentcorrection/20624887-17351619, http://linkedlifedata.com/resource/pubmed/commentcorrection/20624887-17899546, http://linkedlifedata.com/resource/pubmed/commentcorrection/20624887-18218322, http://linkedlifedata.com/resource/pubmed/commentcorrection/20624887-18221509, http://linkedlifedata.com/resource/pubmed/commentcorrection/20624887-18400187, http://linkedlifedata.com/resource/pubmed/commentcorrection/20624887-19151191, http://linkedlifedata.com/resource/pubmed/commentcorrection/20624887-19262671, http://linkedlifedata.com/resource/pubmed/commentcorrection/20624887-19749004, http://linkedlifedata.com/resource/pubmed/commentcorrection/20624887-20008288, http://linkedlifedata.com/resource/pubmed/commentcorrection/20624887-20064452, http://linkedlifedata.com/resource/pubmed/commentcorrection/20624887-7507889, http://linkedlifedata.com/resource/pubmed/commentcorrection/20624887-8309034, http://linkedlifedata.com/resource/pubmed/commentcorrection/20624887-9526191
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1540-9538
pubmed:author
pubmed:issnType
Electronic
pubmed:day
2
pubmed:volume
207
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1609-16
pubmed:dateRevised
2011-7-22
pubmed:meshHeading
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