Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2010-10-6
pubmed:abstractText
Gambogic acid (GA) is the major active compound of Gamboge, a brownish or orange resin exuded from Garcinia hanburryi tree in Southeast Asia. Previous studies have demonstrated that GA exhibits potent anticancer effects by inducing cell cycle arrest or apoptosis in many types of cancer cell lines and blocking angiogenesis via inhibition of vascular endothelial cell proliferation and migration. Proliferation and migration of vascular smooth muscle cells (VSMCs) are critical steps in the progress of atherosclerosis and restenosis after angioplasty. In the present study, we investigated whether GA has an inhibitory effect on the proliferation and migration of VSMCs and its possible mechanism.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1880-3873
pubmed:author
pubmed:issnType
Electronic
pubmed:day
30
pubmed:volume
17
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
901-13
pubmed:meshHeading
pubmed-meshheading:20543524-Animals, pubmed-meshheading:20543524-Cell Cycle, pubmed-meshheading:20543524-Cell Movement, pubmed-meshheading:20543524-Cell Proliferation, pubmed-meshheading:20543524-Cell Survival, pubmed-meshheading:20543524-Cells, Cultured, pubmed-meshheading:20543524-Cyclins, pubmed-meshheading:20543524-DNA, pubmed-meshheading:20543524-Epidermal Growth Factor, pubmed-meshheading:20543524-G0 Phase, pubmed-meshheading:20543524-G1 Phase, pubmed-meshheading:20543524-Myocytes, Smooth Muscle, pubmed-meshheading:20543524-Phosphorylation, pubmed-meshheading:20543524-Platelet-Derived Growth Factor, pubmed-meshheading:20543524-Rats, pubmed-meshheading:20543524-Receptor, Platelet-Derived Growth Factor beta, pubmed-meshheading:20543524-Signal Transduction, pubmed-meshheading:20543524-Tyrosine, pubmed-meshheading:20543524-Xanthones, pubmed-meshheading:20543524-rac1 GTP-Binding Protein
pubmed:year
2010
pubmed:articleTitle
Gambogic acid induces G0/G1 cell cycle arrest and cell migration inhibition via suppressing PDGF receptor ? tyrosine phosphorylation and Rac1 activity in rat aortic smooth muscle cells.
pubmed:affiliation
Department of Vascular Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guandong, China.
pubmed:publicationType
Journal Article