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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1991-7-19
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pubmed:abstractText |
The activity of carnitine acetyltransferase (acetyl-CoA:L-carnitine O-acetyltransferase) was found to be at least 50-fold higher than that of choline acetyltransferase in PC12 cells. Nerve growth factor stimulated both enzymes in a parallel manner with respect to concentration of NGF and culture time. The stimulation of both enzymes was completely inhibited by 10 microM 6-thioguanine, an inhibitor of protein kinase N. Results are discussed with reference to the hypothesis that the two enzymes may be functionally related in neuronal cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0364-3190
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
63-6
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:2052139-Adrenal Gland Neoplasms,
pubmed-meshheading:2052139-Animals,
pubmed-meshheading:2052139-Carnitine O-Acetyltransferase,
pubmed-meshheading:2052139-Choline O-Acetyltransferase,
pubmed-meshheading:2052139-Nerve Growth Factors,
pubmed-meshheading:2052139-Pheochromocytoma,
pubmed-meshheading:2052139-Protein Kinase C,
pubmed-meshheading:2052139-Protein Kinase Inhibitors,
pubmed-meshheading:2052139-Rats,
pubmed-meshheading:2052139-Thioguanine,
pubmed-meshheading:2052139-Tumor Cells, Cultured
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pubmed:year |
1991
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pubmed:articleTitle |
Stimulation of carnitine acetyltransferase in PC12 cells by nerve growth factor: relationship to choline acetyltransferase stimulation.
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pubmed:affiliation |
Div. of Pharmacology, Wellcome Research Laboratories, Research Triangle Park, North Carolina 27709.
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pubmed:publicationType |
Journal Article,
Comparative Study
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