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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2010-11-24
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pubmed:abstractText |
Successful clinical organ preservations are a prerequisite for organ transplantation. Diazoxide (DE), which shows a concentration-dependent selectivity for mitoK(+-)-ATP over plasma membrane K(+-)-ATP, displays protective effects during organ preservation. The current study investigated possible protective effects of DE on rat kidneys injured by hypothermic preservation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Casp12 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Caspase 12,
http://linkedlifedata.com/resource/pubmed/chemical/Celsior,
http://linkedlifedata.com/resource/pubmed/chemical/Cryoprotective Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Ddit3 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Diazoxide,
http://linkedlifedata.com/resource/pubmed/chemical/Disaccharides,
http://linkedlifedata.com/resource/pubmed/chemical/Electrolytes,
http://linkedlifedata.com/resource/pubmed/chemical/Glutamates,
http://linkedlifedata.com/resource/pubmed/chemical/Glutathione,
http://linkedlifedata.com/resource/pubmed/chemical/Histidine,
http://linkedlifedata.com/resource/pubmed/chemical/Malondialdehyde,
http://linkedlifedata.com/resource/pubmed/chemical/Mannitol,
http://linkedlifedata.com/resource/pubmed/chemical/Organ Preservation Solutions,
http://linkedlifedata.com/resource/pubmed/chemical/Superoxide Dismutase,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factor CHOP
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1460-2385
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3859-67
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pubmed:meshHeading |
pubmed-meshheading:20513771-Acute Kidney Injury,
pubmed-meshheading:20513771-Animals,
pubmed-meshheading:20513771-Apoptosis,
pubmed-meshheading:20513771-Caspase 12,
pubmed-meshheading:20513771-Cryoprotective Agents,
pubmed-meshheading:20513771-Diazoxide,
pubmed-meshheading:20513771-Disaccharides,
pubmed-meshheading:20513771-Down-Regulation,
pubmed-meshheading:20513771-Electrolytes,
pubmed-meshheading:20513771-Epithelial Cells,
pubmed-meshheading:20513771-Glutamates,
pubmed-meshheading:20513771-Glutathione,
pubmed-meshheading:20513771-Histidine,
pubmed-meshheading:20513771-Hypothermia,
pubmed-meshheading:20513771-Kidney Tubules,
pubmed-meshheading:20513771-Male,
pubmed-meshheading:20513771-Malondialdehyde,
pubmed-meshheading:20513771-Mannitol,
pubmed-meshheading:20513771-Models, Animal,
pubmed-meshheading:20513771-Organ Preservation Solutions,
pubmed-meshheading:20513771-Oxidative Stress,
pubmed-meshheading:20513771-Rats,
pubmed-meshheading:20513771-Rats, Sprague-Dawley,
pubmed-meshheading:20513771-Superoxide Dismutase,
pubmed-meshheading:20513771-Transcription Factor CHOP
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pubmed:year |
2010
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pubmed:articleTitle |
Diazoxide attenuates hypothermic preservation-induced renal injury via down-regulation of CHOP and caspase-12.
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pubmed:affiliation |
Department of Anatomy and Cell Biology, School of Medicine, Zhejiang University, Hangzhou 310058, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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