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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2010-5-4
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pubmed:abstractText |
In utero tracheal occlusion (TO) has been developed to improve the lung hypoplasia associated with congenital diaphragmatic hernia (CDH). However, although TO stimulates fetal lung growth, it results in a decrease of alveolar type II cells (ATII) and surfactant production. Because keratinocyte growth factor (KGF) is a potent stimulus of ATII proliferation and maturation, we evaluated, in a fetal lamb model of CDH, a gene therapy strategy combining TO and ovine KGF transfection into the fetal airways using bisguanidinium-tren-cholesterol/dioleoyl-phosphatidylethanolamine (BGTC/DOPE) cationic liposomes.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1521-2254
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pubmed:author |
pubmed-author:AigrainYvesY,
pubmed-author:AissaouiAbderrahimA,
pubmed-author:BonnardArnaudA,
pubmed-author:HauchecorneMichelleM,
pubmed-author:LehnJean-MarieJM,
pubmed-author:LehnPierreP,
pubmed-author:LutonDominiqueD,
pubmed-author:OudrhiriNoufissaN,
pubmed-author:OuryJean-FrançoisJF,
pubmed-author:PeuchmaurMichelM,
pubmed-author:SaadaJulienJ,
pubmed-author:de LagausiePascalP
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pubmed:copyrightInfo |
Copyright (c) 2010 John Wiley & Sons, Ltd.
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pubmed:issnType |
Electronic
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
413-22
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pubmed:meshHeading |
pubmed-meshheading:20440752-Animals,
pubmed-meshheading:20440752-Disease Models, Animal,
pubmed-meshheading:20440752-Fetus,
pubmed-meshheading:20440752-Fibroblast Growth Factor 7,
pubmed-meshheading:20440752-Gene Expression Regulation, Developmental,
pubmed-meshheading:20440752-Hernia, Diaphragmatic,
pubmed-meshheading:20440752-Lung,
pubmed-meshheading:20440752-Organ Size,
pubmed-meshheading:20440752-Pulmonary Alveoli,
pubmed-meshheading:20440752-Pulmonary Surfactant-Associated Protein B,
pubmed-meshheading:20440752-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:20440752-Sheep,
pubmed-meshheading:20440752-Trachea,
pubmed-meshheading:20440752-Transfection
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pubmed:year |
2010
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pubmed:articleTitle |
Combining keratinocyte growth factor transfection into the airways and tracheal occlusion in a fetal sheep model of congenital diaphragmatic hernia.
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pubmed:affiliation |
EA 3102, Hôpital Robert Debré, AP-HP, Paris, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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