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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2010-4-27
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pubmed:abstractText |
Pregnancy is widely viewed as dependent upon an intimate dialogue, mediated by locally secreted factors between a developmentally competent embryo and a receptive endometrium. Reproductive success in humans is however limited, largely because of the high prevalence of chromosomally abnormal preimplantation embryos. Moreover, the transient period of endometrial receptivity in humans uniquely coincides with differentiation of endometrial stromal cells (ESCs) into highly specialized decidual cells, which in the absence of pregnancy invariably triggers menstruation. The role of cyclic decidualization of the endometrium in the implantation process and the nature of the decidual cytokines and growth factors that mediate the crosstalk with the embryo are unknown.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:issn |
1932-6203
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pubmed:author |
pubmed-author:AojanepongTepchongchitT,
pubmed-author:BCC,
pubmed-author:BrosensJan JJJ,
pubmed-author:HeijnenCobi JCJ,
pubmed-author:KavelaarsAnnemiekeA,
pubmed-author:KuijkEwart WEW,
pubmed-author:LandlesChristianC,
pubmed-author:LaveryStuartS,
pubmed-author:LokugamageAmali UAU,
pubmed-author:MacklonNick SNS,
pubmed-author:MardonHelen JHJ,
pubmed-author:MolokhiaMariamM,
pubmed-author:QuenbySiobhanS,
pubmed-author:ReganLesleyL,
pubmed-author:RoelenBernard A JBA,
pubmed-author:SalkerMadhuriM,
pubmed-author:TeklenburgGijsG,
pubmed-author:TrewGeoffreyG
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pubmed:issnType |
Electronic
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
e10258
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pubmed:meshHeading |
pubmed-meshheading:20422011-Biosensing Techniques,
pubmed-meshheading:20422011-Coculture Techniques,
pubmed-meshheading:20422011-Embryo, Mammalian,
pubmed-meshheading:20422011-Embryo Implantation,
pubmed-meshheading:20422011-Embryonic Stem Cells,
pubmed-meshheading:20422011-Endometrium,
pubmed-meshheading:20422011-Female,
pubmed-meshheading:20422011-Genetic Fitness,
pubmed-meshheading:20422011-Humans,
pubmed-meshheading:20422011-Pregnancy,
pubmed-meshheading:20422011-Selection, Genetic,
pubmed-meshheading:20422011-Stromal Cells
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pubmed:year |
2010
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pubmed:articleTitle |
Natural selection of human embryos: decidualizing endometrial stromal cells serve as sensors of embryo quality upon implantation.
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pubmed:affiliation |
Department of Reproductive Medicine and Gynecology, University Medical Center Utrecht, Utrecht, The Netherlands.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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