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rdf:type |
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lifeskim:mentions |
umls-concept:C0004561,
umls-concept:C0027280,
umls-concept:C0032659,
umls-concept:C0152035,
umls-concept:C0439849,
umls-concept:C0445223,
umls-concept:C0752046,
umls-concept:C0919428,
umls-concept:C1136197,
umls-concept:C1154779,
umls-concept:C1413742,
umls-concept:C1511790,
umls-concept:C1551910,
umls-concept:C1552599,
umls-concept:C1704787,
umls-concept:C1882417,
umls-concept:C2826170
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pubmed:issue |
7
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pubmed:dateCreated |
2010-4-14
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pubmed:abstractText |
Single-nucleotide polymorphisms (SNP) in genes coding metabolizing enzymes modulate gene functions and cellular toxicity in response to chemicals. Quinone oxidoreductase 1 (NQO1) is an important detoxification enzyme involved in the catabolism of 1,4-benzoquinone (1,4-BQ), a benzene metabolite believed to be associated with bone-marrow toxicity and leukemia. Gene function was evaluated in immortalized human B lymphocytes derived from a Chinese Han population with independent genotypes at 2 NQO1 SNP sites. 1,4-Benzoquinone was incubated with these immortalized lymphocytes of differing genotypes. Among the genotypes of 2 SNP examined, cell lines with rs1800566CC showed a higher NQO1 enzymic activity after a 48 h of treatment with 10 muM 1,4-BQ, and a lower comet rate compared with cells of CT/TT genotypes. Data suggested that NQO1 rs1800566 might serve as a functional genetic marker for benzene toxicity in the Chinese Han population. The immortalized B lymphocytes derived from different populations might thus be used as a biomarker to detect functional genetic markers related to exposure to environmental chemicals.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1528-7394
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
73
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
490-8
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pubmed:dateRevised |
2011-2-2
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pubmed:meshHeading |
pubmed-meshheading:20391128-Adolescent,
pubmed-meshheading:20391128-Adult,
pubmed-meshheading:20391128-B-Lymphocytes,
pubmed-meshheading:20391128-Benzene,
pubmed-meshheading:20391128-Benzoquinones,
pubmed-meshheading:20391128-Cell Line,
pubmed-meshheading:20391128-Cell Proliferation,
pubmed-meshheading:20391128-China,
pubmed-meshheading:20391128-DNA Damage,
pubmed-meshheading:20391128-DNA Fingerprinting,
pubmed-meshheading:20391128-Enzyme Induction,
pubmed-meshheading:20391128-Female,
pubmed-meshheading:20391128-Humans,
pubmed-meshheading:20391128-Male,
pubmed-meshheading:20391128-Middle Aged,
pubmed-meshheading:20391128-NAD(P)H Dehydrogenase (Quinone),
pubmed-meshheading:20391128-Polymorphism, Single Nucleotide,
pubmed-meshheading:20391128-RNA, Messenger,
pubmed-meshheading:20391128-Young Adult
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pubmed:year |
2010
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pubmed:articleTitle |
Detection of quinone oxidoreductase 1 (NQO1) single-nucleotide polymorphisms (SNP) related to benzene metabolism in immortalized B lymphocytes from a Chinese Han population.
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pubmed:affiliation |
Key Laboratory of Environmental Medicine and Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing, People's Republic of China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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