Linked Life Data

2019575

Source:http://linkedlifedata.com/resource/pubmed/id/2019575

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
1991-5-29
pubmed:abstractText
Habituation in response to repetitive depolarization of PC12 cells can be used as a model for memory processes at the molecular level. In response to depolarization by high external potassium, a triphasic elevation in internal calcium levels occurred. Calcium elevation was maximal immediately after addition of the stimulus (phase 1), followed by a 2-min period in which the calcium level decreased (phase 2), leading to a new steady-state level which was higher than in the unstimulated cell (phase 3). In response to repetitive depolarizations, the calcium level in phase 1 was reduced by as much as 43%, and phase 3 was reduced by as much as 40%. By measuring the relationship between calcium elevation and secretion, it was shown that measured reductions in calcium levels were correlated with neurosecretory habituation. One of the components responsible for the reductions in calcium levels was a tetraethylammonium-sensitive potassium channel, and the habituation of this channel was reversed by addition of 4 beta-phorbol 12-myristate 13-acetate.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0021-9258
pubmed:author
pubmed:issnType
Print
pubmed:day
25
pubmed:volume
266
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
7388-92
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
The biochemistry of the neuron. Neurosecretory habituation to repetitive depolarizations in PC12 cells.
pubmed:affiliation
Department of Molecular and Cell Biology, University of California, Berkeley 94720.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't