Linked Life Data

20167796

Source:http://linkedlifedata.com/resource/pubmed/id/20167796

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2010-6-14
pubmed:abstractText
A rapid bioassay method has been developed for the determination of (90)Sr in human urine samples. The method is based on on-cartridge decolourisation of urine sample, separation of (90)Y from (90)Sr on an anion exchange resin column and by determination of (90)Sr using a liquid scintillation analyser (LSA). Separation of (90)Y from (90)Sr was achieved through selective complexation of yttrium with phosphate and subsequent retention of the anionic yttrium phosphate species on anion exchange resin. A total recovery of 97 +/- 2 % was obtained for strontium with three washes. The minimum detectable activity for the method was 0.2 Bq or 40 Bq l(-1). Measurement accuracy (relative bias, B(r)) and repeatability (relative precision, S(B)) of the method for the determination of (90)Sr were found to be -1 and 4.7 %, respectively. Excellent linearity (r(2) > 0.999) was established over an activity range from 3.25 x 10(2) to 3.25 x 10(4) Bq l(-1). The method was also found to be very robust (S(B) < 5 %) against the matrix effect from different urine samples. Performance of the rapid bioassay method for sensitivity, accuracy and repeatability evaluated against the performance criteria for radiobioassay (ANSI N13.30) was found to be in compliant. Considering the simplicity, excellent analytical figures of merit, fast sample turnaround time (<1 h) and cost efficiency (<30 USD per sample) of the developed method, it is very promising as a rapid bioassay method for supporting the medical response to an emergency where internal contamination of (90)Sr is involved.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1742-3406
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
140
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
41-8
pubmed:dateRevised
2010-11-10
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
A rapid bioassay method for the determination of 90Sr in human urine sample.
pubmed:affiliation
Radiation Protection Bureau, Health Canada, 775 Brookfield Road, Ottawa, ON, Canada K1A 1C1.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't