Linked Life Data

20058084

Source:http://linkedlifedata.com/resource/pubmed/id/20058084

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2010-4-26
pubmed:abstractText
Lithium naphthalocyanine (LiNc) is a crystalline material that has significant potential as a probe for EPR (electron paramagnetic resonance)-based biological oximetry (Pandian et al. J. Mater. Chem. 19:4138-4147, 2009a). However, implantation of LiNc crystals in tissues in raw or neat form is undesirable since dispersion of crystals in tissue may lead to loss of EPR signal, while also exacerbating biocompatibility concerns due to tissue exposure. To overcome these concerns, we have encapsulated LiNc crystals in an oxygen-permeable polymer, Teflon AF 2400 (TAF). Fabrication of TAF films incorporating LiNc particles (denoted as LiNc:TAF chip) was carried out using solvent-evaporation techniques. The EPR linewidth of LiNc:TAF chip was linearly dependent on oxygen-partial pressure (pO(2)) and did not change significantly relative to neat LiNc crystals. LiNc:TAF chip responded to changes in pO(2) reproducibly, enabling dynamic measurements of oxygenation in real time. The LiNc:TAF chips were stable in tissues for more than 2 months and were capable of providing repeated measurements of tissue oxygenation for extended periods of time. The results demonstrated that the newly fabricated, highly oxygen-sensitive LiNc:TAF chip will enhance the applicability of EPR oximetry for long-term and clinical applications.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/20058084-14572616, http://linkedlifedata.com/resource/pubmed/commentcorrection/20058084-15130286, http://linkedlifedata.com/resource/pubmed/commentcorrection/20058084-15334586, http://linkedlifedata.com/resource/pubmed/commentcorrection/20058084-16368480, http://linkedlifedata.com/resource/pubmed/commentcorrection/20058084-16927719, http://linkedlifedata.com/resource/pubmed/commentcorrection/20058084-17576162, http://linkedlifedata.com/resource/pubmed/commentcorrection/20058084-17822371, http://linkedlifedata.com/resource/pubmed/commentcorrection/20058084-18843166, http://linkedlifedata.com/resource/pubmed/commentcorrection/20058084-19291409, http://linkedlifedata.com/resource/pubmed/commentcorrection/20058084-19319683, http://linkedlifedata.com/resource/pubmed/commentcorrection/20058084-8390665
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1572-8781
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
381-7
pubmed:dateRevised
2011-7-28
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
An implantable Teflon chip holding lithium naphthalocyanine microcrystals for secure, safe, and repeated measurements of pO2 in tissues.
pubmed:affiliation
Center for Biomedical EPR Spectroscopy and Imaging, The Ohio State University, 420 West 12th Avenue, Room 114, Columbus, OH 43210, USA.
pubmed:publicationType
Journal Article, Evaluation Studies, Research Support, N.I.H., Extramural