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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1991-4-2
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pubmed:abstractText |
Thalidomide selectively inhibits the production of human monocyte tumor necrosis factor alpha (TNF-alpha) when these cells are triggered with lipopolysaccharide and other agonists in culture. 40% inhibition occurs at the clinically achievable dose of the drug of 1 micrograms/ml. In contrast, the amount of total protein and individual proteins labeled with [35S]methionine and expressed on SDS-PAGE are not influenced. The amounts of interleukin 1 beta (IL-1 beta), IL-6, and granulocyte/macrophage colony-stimulating factor produced by monocytes remain unaltered. The selectivity of this drug may be useful in determining the role of TNF-alpha in vivo and modulating its toxic effects in a clinical setting.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1997652-13934699,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1997652-2110362,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1997652-2113553,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1997652-2509559,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1997652-2783334,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1997652-2786029,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1997652-2878227,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1997652-2890853,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1997652-3135497,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1997652-3263392,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1997652-3351436,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1997652-3414726,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1997652-3484390,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1997652-3491987,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1997652-3607879,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1997652-3754653,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1997652-3874920,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1997652-5792378,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1997652-6200537,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1997652-7130490
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
173
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
699-703
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:1997652-Blood Proteins,
pubmed-meshheading:1997652-Cytokines,
pubmed-meshheading:1997652-Endotoxins,
pubmed-meshheading:1997652-Humans,
pubmed-meshheading:1997652-Kinetics,
pubmed-meshheading:1997652-Lipopolysaccharides,
pubmed-meshheading:1997652-Molecular Weight,
pubmed-meshheading:1997652-Monocytes,
pubmed-meshheading:1997652-Salmonella,
pubmed-meshheading:1997652-Thalidomide,
pubmed-meshheading:1997652-Tumor Necrosis Factor-alpha
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pubmed:year |
1991
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pubmed:articleTitle |
Thalidomide selectively inhibits tumor necrosis factor alpha production by stimulated human monocytes.
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pubmed:affiliation |
Laboratory of Cellular Physiology and Immunology, Rockefeller University, New York, New York 10021.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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