|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:dateCreated |
2009-12-1
|
|
pubmed:abstractText |
Apopotosis of osteoclasts is regulated by the Bcl-2 family protein Bim. Bim is degraded in the course of osteoclast apoptosis, which is regulated by Caspase-3. Osteoclasts generated from caspase-3 -/- mice exhibited a shorter life span and a higher bone-resorbing activity than those generated from normal littermates. These results suggest the important role of Caspase-3-Bim axis in regulating both apoptosis and activation of osteoclasts.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
0065-2598
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
658
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
111-6
|
|
pubmed:meshHeading |
pubmed-meshheading:19950021-Animals,
pubmed-meshheading:19950021-Apoptosis,
pubmed-meshheading:19950021-Apoptosis Regulatory Proteins,
pubmed-meshheading:19950021-Caspase 3,
pubmed-meshheading:19950021-Cell Survival,
pubmed-meshheading:19950021-Down-Regulation,
pubmed-meshheading:19950021-Embryo, Mammalian,
pubmed-meshheading:19950021-Fibroblasts,
pubmed-meshheading:19950021-Membrane Proteins,
pubmed-meshheading:19950021-Mice,
pubmed-meshheading:19950021-Models, Biological,
pubmed-meshheading:19950021-Osteoclasts,
pubmed-meshheading:19950021-Proto-Oncogene Proteins
|
|
pubmed:year |
2010
|
|
pubmed:articleTitle |
Regulation of osteoclast apoptosis by Bcl-2 family protein Bim and Caspase-3.
|
|
pubmed:affiliation |
Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, Tokyo, Japan. tanakas-ort@h.u-tokyo.ac.jp
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
