|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
2010-2-18
|
|
pubmed:abstractText |
In 2008, the National Comprehensive Cancer Network suggested conducting a KRAS mutations test in metastatic colorectal cancer (mCRC) patients prior to administering therapy that uses anti-epidermal growth factor receptor (EGFR) monoclonal antibody. However, tests of KRAS mutations have been limited when traditional molecular techniques, such as polymerase chain reaction (PCR) combined direct sequencing, are used to obtain and analyze patients' cancer tissues. If the primary tumor or metastatic tissues of patients with mCRC is unavailable, then such analysis will not be feasible. Our laboratory has successfully established a colorimetric membrane array analysis platform that could detect activating KRAS mutations from the peripheral blood of patients with various malignancies.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Feb
|
|
pubmed:issn |
1534-4681
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
17
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
624-33
|
|
pubmed:meshHeading |
pubmed-meshheading:19937133-Aged,
pubmed-meshheading:19937133-Breast Neoplasms,
pubmed-meshheading:19937133-Carcinoma, Non-Small-Cell Lung,
pubmed-meshheading:19937133-Colorectal Neoplasms,
pubmed-meshheading:19937133-Female,
pubmed-meshheading:19937133-Gene Expression Profiling,
pubmed-meshheading:19937133-Humans,
pubmed-meshheading:19937133-Luminescence,
pubmed-meshheading:19937133-Lung Neoplasms,
pubmed-meshheading:19937133-Male,
pubmed-meshheading:19937133-Membranes, Artificial,
pubmed-meshheading:19937133-Neoplastic Cells, Circulating,
pubmed-meshheading:19937133-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:19937133-Proto-Oncogene Proteins,
pubmed-meshheading:19937133-Sensitivity and Specificity,
pubmed-meshheading:19937133-Tumor Markers, Biological,
pubmed-meshheading:19937133-ras Proteins
|
|
pubmed:year |
2010
|
|
pubmed:articleTitle |
Enhancing detection of circulating tumor cells with activating KRAS oncogene in patients with colorectal cancer by weighted chemiluminescent membrane array method.
|
|
pubmed:affiliation |
Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
|
|
pubmed:publicationType |
Journal Article,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
|
