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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0025914,
umls-concept:C0026559,
umls-concept:C0026809,
umls-concept:C0040688,
umls-concept:C0185117,
umls-concept:C0205245,
umls-concept:C0242275,
umls-concept:C0871161,
umls-concept:C0929301,
umls-concept:C1512083,
umls-concept:C2911684
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pubmed:issue |
1
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pubmed:dateCreated |
1991-2-14
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pubmed:abstractText |
Primer-directed enzyme amplification was used to examine epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha) mRNA transcripts in mammary glands of young virgin, mature virgin, midpregnant, and midlactating mice. Transcripts for both EGF and TGF-alpha mRNA were detected in virgin and pregnant mice, whereas transcripts for EGF mRNA but not TGF-alpha mRNA were expressed in 10-day lactating mice. TGF-alpha was localized in the epithelial cap-cell layer of the advancing terminal end bud and in the stromal fibroblasts at the base of the terminal end bud; EGF was localized in the inner layers of the terminal end bud and in ductal cells of mammary epithelium. Implantation of pellets containing EGF or TGF-alpha into the regressed mammary gland of ovariectomized mice stimulated the reappearance of end buds; contralateral glands implanted with pellets containing albumin or insulin were not affected. These results indicate that an EGF-receptor-mediated pathway remained intact in the mammary gland epithelium in the absence of ovarian steroids and that local availability of either EGF or TGF-alpha is sufficient to stimulate the pattern of normal ductal growth. The detection of EGF and TFF-alpha transcripts at different stages of mammary gland development and the different patterns of immunolocalization suggest that each polypeptide plays a different role in normal mammary gland morphogenesis.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1986376-13611531,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1986376-13821714,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1986376-14281193,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1986376-2358112,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1986376-2442615,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1986376-2448875,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1986376-2477693,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1986376-2484711,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1986376-2551762,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1986376-2655477,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1986376-2783757,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1986376-2786419,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1986376-2925270,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1986376-2996761,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1986376-3000728,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1986376-3001700,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1986376-302030,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1986376-3047554,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1986376-3084797,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1986376-3175624,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1986376-3191480,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1986376-3259938,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1986376-3286224,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1986376-3459590,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1986376-3465381,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1986376-3467839,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1986376-3486321,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1986376-3491676,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1986376-3574460,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1986376-3593682,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1986376-3664507,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1986376-3855503,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1986376-3870134,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1986376-3871506,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1986376-3882412,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1986376-3940197,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1986376-4370002,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1986376-4504350,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1986376-6088071,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1986376-6319502,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1986376-6320373,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1986376-6331663,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1986376-6600687,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1986376-6602382,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1986376-6605295,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1986376-6745187,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1986376-6825106,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1986376-6852366,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1986376-6961412,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1986376-6966378,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1986376-6968093,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1986376-6982824,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1986376-7033366,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1986376-972168
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
88
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
276-80
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:1986376-Animals,
pubmed-meshheading:1986376-Mice,
pubmed-meshheading:1986376-Pregnancy,
pubmed-meshheading:1986376-Lactation,
pubmed-meshheading:1986376-Ovariectomy,
pubmed-meshheading:1986376-Epidermal Growth Factor,
pubmed-meshheading:1986376-Mammary Glands, Animal,
pubmed-meshheading:1986376-Female,
pubmed-meshheading:1986376-Sexual Maturation,
pubmed-meshheading:1986376-Mice, Inbred Strains
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