Linked Life Data

19796972

Source:http://linkedlifedata.com/resource/pubmed/id/19796972

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2010-12-6
pubmed:abstractText
Muscarinic acetylcholine (M) and adrenergic (AR) receptors mediate gastrointestinal motility. Using radioligand binding assays and real-time polymerase chain reaction, the densities of binding sites and mRNA levels of M?, M?, ??(AD)- and ??-AR were compared in muscle tissues from the abomasal fundus, pylorus, duodenum, caecum, and external loop of the spiral colon of eight cows with left displacement of abomasum (LDA), and of eight healthy cows. Specific binding of the [³H]-ligands to each of the four receptors was competitive and saturable. Binding sites of M? (all intestinal sites), M? (duodenum and caecum), and of ??(AD)-AR (abomasal fundus) were lower (P < 0.05) in cows with LDA than in healthy cows. The coefficients of correlation between binding sites and mRNA transcripts of receptors were dissimilar in cows with LDA and healthy cows. The decrease in densities of M (intestine) and of ??(AD)-AR (abomasum) receptors suggests their implication in the impairment of motility associated with or leading to LDA.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1532-2971
pubmed:author
pubmed:copyrightInfo
Copyright © 2009 Elsevier Ltd. All rights reserved.
pubmed:issnType
Electronic
pubmed:volume
186
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
328-37
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Binding sites of muscarinic and adrenergic receptors in gastrointestinal tissues of dairy cows suffering from left displacement of the abomasum.
pubmed:affiliation
Clinic for Ruminants, Vetsuisse Faculty, University of Berne, CH-3012 Berne, Switzerland. edgar.ontsouka@physio.unibe.ch
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't