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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2010-1-7
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pubmed:abstractText |
The transition from acute to chronic graft-versus-host disease (aGVHD, cGVHD) is characterized by the progressive loss of self-tolerance and the development of autoimmune manifestations. Interleukin 17 (IL-17) is a proinflammatory cytokine that has been shown to play a prominent role in autoimmune disorders in the nontransplant setting, but the extent to which IL-17 is necessary for the autoimmunity that occurs as a consequence of GVHD is not known. In this study, we demonstrate using a combination of antibody-based and genetic approaches that IL-17 is not required for the loss of self-tolerance and resulting CD4(+)T cell-dependent pathologic damage that occurs during the evolution from aGVHD to cGVHD. Rather, T(H)1 cells and other proinflammatory cytokines are fully competent to promote autoimmune-mediated tissue damage. Thus, the selective targeting of IL-17 may not be a viable clinical strategy for preventing the autoimmune manifestations that develop during cGVHD.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19772944-12574382,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19772944-14634133,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19772944-16338616,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19772944-16473830,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19772944-16648838,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19772944-16785554,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19772944-17048276,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19772944-17129175,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19772944-1732411,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19772944-17693581,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19772944-17911448,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19772944-18550852,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19772944-18596226,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19772944-18931341,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19772944-18957685,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19772944-19059877,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19772944-19168793,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19772944-19491393,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19772944-3043780,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19772944-3297128,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19772944-3316469,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19772944-8676080,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19772944-9834129
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1523-6536
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pubmed:author |
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pubmed:copyrightInfo |
Copyright (c) 2010 American Society for Blood and Marrow Transplantation. Published by Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
123-8
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pubmed:dateRevised |
2011-7-19
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pubmed:meshHeading |
pubmed-meshheading:19772944-Animals,
pubmed-meshheading:19772944-Autoimmune Diseases,
pubmed-meshheading:19772944-Bone Marrow Transplantation,
pubmed-meshheading:19772944-CD4 Lymphocyte Count,
pubmed-meshheading:19772944-CD4-Positive T-Lymphocytes,
pubmed-meshheading:19772944-Chimera,
pubmed-meshheading:19772944-Chronic Disease,
pubmed-meshheading:19772944-Colon,
pubmed-meshheading:19772944-Cytokines,
pubmed-meshheading:19772944-Disease Progression,
pubmed-meshheading:19772944-Flow Cytometry,
pubmed-meshheading:19772944-Graft vs Host Disease,
pubmed-meshheading:19772944-Interleukin-17,
pubmed-meshheading:19772944-Lymphocytes,
pubmed-meshheading:19772944-Mice,
pubmed-meshheading:19772944-Mice, Inbred BALB C,
pubmed-meshheading:19772944-Mice, Inbred C57BL,
pubmed-meshheading:19772944-Mucous Membrane,
pubmed-meshheading:19772944-Organ Specificity,
pubmed-meshheading:19772944-Signal Transduction
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pubmed:year |
2010
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pubmed:articleTitle |
Interleukin 17 is not required for autoimmune-mediated pathologic damage during chronic graft-versus-host disease.
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pubmed:affiliation |
Bone Marrow Transplant Program, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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