19765303

Source:http://linkedlifedata.com/resource/pubmed/id/19765303

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0385463, umls-concept:C0681842, umls-concept:C1140680, umls-concept:C1274040, umls-concept:C1514559, umls-concept:C2698217
pubmed:dateCreated	2009-9-30
pubmed:abstractText	Recent epidemiological studies have suggested that obesity is associated with ovarian cancer. Obesity hormone leptin and its receptor (Ob-R) contribute to tumor development by enhancing cell growth and survival. This study was design to investigate the prevalence of leptin and Ob-R in Middle Eastern epithelial ovarian cancer (EOC) and to analyze the role of leptin and the mechanisms under its action in EOC tissue sample and cell lines.
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pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/101147698
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Culture Media, Serum-Free, http://linkedlifedata.com/resource/pubmed/chemical/Leptin, http://linkedlifedata.com/resource/pubmed/chemical/Oncogene Protein v-akt, http://linkedlifedata.com/resource/pubmed/chemical/Phosphatidylinositol 3-Kinases, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Leptin
pubmed:status	MEDLINE
pubmed:issn	1476-4598
pubmed:author	pubmed-author:AbubakerJehadJ, pubmed-author:AhmedMaqboolM, pubmed-author:Al-DayelFouadF, pubmed-author:Al-KurayaKhawla SKS, pubmed-author:BaviPrashantP, pubmed-author:BuRongR, pubmed-author:UddinShahabS
pubmed:issnType	Electronic
pubmed:volume	8
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	74
pubmed:dateRevised	2010-11-18
pubmed:meshHeading	pubmed-meshheading:19765303-Apoptosis, pubmed-meshheading:19765303-Cell Line, Tumor, pubmed-meshheading:19765303-Cell Proliferation, pubmed-meshheading:19765303-Culture Media, Serum-Free, pubmed-meshheading:19765303-Disease Progression, pubmed-meshheading:19765303-Dose-Response Relationship, Drug, pubmed-meshheading:19765303-Epithelium, pubmed-meshheading:19765303-Female, pubmed-meshheading:19765303-Humans, pubmed-meshheading:19765303-Immunohistochemistry, pubmed-meshheading:19765303-Kaplan-Meier Estimate, pubmed-meshheading:19765303-Leptin, pubmed-meshheading:19765303-Middle Aged, pubmed-meshheading:19765303-Middle East, pubmed-meshheading:19765303-Oncogene Protein v-akt, pubmed-meshheading:19765303-Outcome Assessment (Health Care), pubmed-meshheading:19765303-Ovarian Neoplasms, pubmed-meshheading:19765303-Phosphatidylinositol 3-Kinases, pubmed-meshheading:19765303-Predictive Value of Tests, pubmed-meshheading:19765303-Prognosis, pubmed-meshheading:19765303-Proportional Hazards Models, pubmed-meshheading:19765303-RNA Interference, pubmed-meshheading:19765303-Receptors, Leptin, pubmed-meshheading:19765303-Signal Transduction, pubmed-meshheading:19765303-Tissue Array Analysis
pubmed:year	2009
pubmed:articleTitle	Overexpression of leptin receptor predicts an unfavorable outcome in Middle Eastern ovarian cancer.
pubmed:affiliation	Department of Human Cancer Genomic Research, Research Center, Department of Pathology, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.
pubmed:publicationType	Journal Article