| pubmed-article:1972549 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1972549 | lifeskim:mentions | umls-concept:C0015859 | lld:lifeskim |
| pubmed-article:1972549 | lifeskim:mentions | umls-concept:C0042963 | lld:lifeskim |
| pubmed-article:1972549 | lifeskim:mentions | umls-concept:C0016368 | lld:lifeskim |
| pubmed-article:1972549 | lifeskim:mentions | umls-concept:C0701391 | lld:lifeskim |
| pubmed-article:1972549 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:1972549 | pubmed:dateCreated | 1990-7-25 | lld:pubmed |
| pubmed-article:1972549 | pubmed:abstractText | The intravenous injection of cisplatin (10 mg/kg), the subcutaneous injection of apomorphine (0.125-1 mg/kg) and lisuride (0.001-0.1 mg/kg), the oral administration of ipecacuanha (0.3-2.4 mg/kg) and the intragastric administration of copper sulphate (25-100 mg/kg), induced a vomiting and retching response in the ferret. Pretreatment with dl-fenfluramine (5 mg/kg i.p.) prevented or reduced the emesis induced by cisplatin, apomorphine, ipecacuanha and lisuride but failed to significantly antagonise copper sulphate-induced emesis. The 5-HT3 receptor antagonist ICS 205-930 (0.1 mg/kg i.p.) prevented emesis induced by cisplatin and ipecacuanha but failed to prevent or significantly reduce the emesis induced by apomorphine, lisuride or copper sulphate. Dopamine receptor antagonists, including fluphenazine (0.1-1.0 mg/kg i.p.) prevented apomorphine- and lisuride-induced emesis but were less potent or had inconsistent actions to antagonise cisplatin- or ipecacuanha-induced emesis and failed to inhibit the emesis induced by copper sulphate. The data indicate that dopamine and/or 5-HT3 receptor systems are involved in drug-induced emesis but that emesis caused by gastric irritation induced by copper sulphate is mediated by different receptor mechanisms. | lld:pubmed |
| pubmed-article:1972549 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1972549 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1972549 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1972549 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1972549 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1972549 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1972549 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1972549 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1972549 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1972549 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1972549 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1972549 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1972549 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1972549 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1972549 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1972549 | pubmed:month | May | lld:pubmed |
| pubmed-article:1972549 | pubmed:issn | 0028-3908 | lld:pubmed |
| pubmed-article:1972549 | pubmed:author | pubmed-author:NaylorR JRJ | lld:pubmed |
| pubmed-article:1972549 | pubmed:author | pubmed-author:CostallBB | lld:pubmed |
| pubmed-article:1972549 | pubmed:author | pubmed-author:DomeneyA MAM | lld:pubmed |
| pubmed-article:1972549 | pubmed:author | pubmed-author:RuddJ AJA | lld:pubmed |
| pubmed-article:1972549 | pubmed:author | pubmed-author:TattersallF... | lld:pubmed |
| pubmed-article:1972549 | pubmed:author | pubmed-author:Owera-AtepoJ... | lld:pubmed |
| pubmed-article:1972549 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1972549 | pubmed:volume | 29 | lld:pubmed |
| pubmed-article:1972549 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1972549 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1972549 | pubmed:pagination | 453-62 | lld:pubmed |
| pubmed-article:1972549 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:1972549 | pubmed:meshHeading | pubmed-meshheading:1972549-... | lld:pubmed |
| pubmed-article:1972549 | pubmed:meshHeading | pubmed-meshheading:1972549-... | lld:pubmed |
| pubmed-article:1972549 | pubmed:meshHeading | pubmed-meshheading:1972549-... | lld:pubmed |
| pubmed-article:1972549 | pubmed:meshHeading | pubmed-meshheading:1972549-... | lld:pubmed |
| pubmed-article:1972549 | pubmed:meshHeading | pubmed-meshheading:1972549-... | lld:pubmed |
| pubmed-article:1972549 | pubmed:meshHeading | pubmed-meshheading:1972549-... | lld:pubmed |
| pubmed-article:1972549 | pubmed:meshHeading | pubmed-meshheading:1972549-... | lld:pubmed |
| pubmed-article:1972549 | pubmed:meshHeading | pubmed-meshheading:1972549-... | lld:pubmed |
| pubmed-article:1972549 | pubmed:meshHeading | pubmed-meshheading:1972549-... | lld:pubmed |
| pubmed-article:1972549 | pubmed:meshHeading | pubmed-meshheading:1972549-... | lld:pubmed |
| pubmed-article:1972549 | pubmed:meshHeading | pubmed-meshheading:1972549-... | lld:pubmed |
| pubmed-article:1972549 | pubmed:meshHeading | pubmed-meshheading:1972549-... | lld:pubmed |
| pubmed-article:1972549 | pubmed:meshHeading | pubmed-meshheading:1972549-... | lld:pubmed |
| pubmed-article:1972549 | pubmed:meshHeading | pubmed-meshheading:1972549-... | lld:pubmed |
| pubmed-article:1972549 | pubmed:meshHeading | pubmed-meshheading:1972549-... | lld:pubmed |
| pubmed-article:1972549 | pubmed:meshHeading | pubmed-meshheading:1972549-... | lld:pubmed |
| pubmed-article:1972549 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:1972549 | pubmed:articleTitle | Fluphenazine, ICS 205-930 and dl-fenfluramine differentially antagonise drug-induced emesis in the ferret. | lld:pubmed |
| pubmed-article:1972549 | pubmed:affiliation | Postgraduate Studies in Pharmacology, School of Pharmacy, University of Bradford, West Yorkshire, U.K. | lld:pubmed |
| pubmed-article:1972549 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1972549 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1972549 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1972549 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1972549 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1972549 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1972549 | lld:pubmed |
