Source:http://linkedlifedata.com/resource/pubmed/id/19626635
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
2010-1-13
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pubmed:abstractText |
BACKGROUND.: An activating point mutation of the BRAF oncogene results in a V600E amino acid missense mutation found in a majority of papillary thyroid carcinomas (PTC). METHODS.: In this study, 28 matched tumor and serum samples obtained from patients with both benign and malignant thyroid disorders were analyzed for BRAF mutation using a gap-ligase chain reaction technique. RESULTS.: The BRAF mutation was absent in tumor DNA samples obtained from patients with benign adenomas, follicular neoplasms or carcinoma, and thyroid lymphoma. In contrast, 5 of 14 PTC tumors were positive for the BRAF mutation. Moreover, 3 of 14 patients with PTC were positive for BRAF mutation in serum and tumor. Of these 3 patients, 2 had lymph node metastasis and 2 had PTC in background of the Hashimoto's thyroiditis. CONCLUSIONS.: The detection of free circulating mutant BRAF in patients with PTC is possible and future studies are warranted to determine its clinical significance.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1097-0347
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pubmed:author | |
pubmed:copyrightInfo |
Copyright 2009 Wiley Periodicals, Inc.
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pubmed:issnType |
Electronic
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pubmed:volume |
32
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
229-34
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pubmed:meshHeading |
pubmed-meshheading:19626635-Carcinoma, Papillary,
pubmed-meshheading:19626635-Carcinoma, Papillary, Follicular,
pubmed-meshheading:19626635-DNA, Neoplasm,
pubmed-meshheading:19626635-Exons,
pubmed-meshheading:19626635-Female,
pubmed-meshheading:19626635-Hashimoto Disease,
pubmed-meshheading:19626635-Humans,
pubmed-meshheading:19626635-Lymphatic Metastasis,
pubmed-meshheading:19626635-Male,
pubmed-meshheading:19626635-Middle Aged,
pubmed-meshheading:19626635-Mutation,
pubmed-meshheading:19626635-Polymerase Chain Reaction,
pubmed-meshheading:19626635-Proto-Oncogene Proteins B-raf,
pubmed-meshheading:19626635-Thyroid Neoplasms
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pubmed:year |
2010
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pubmed:articleTitle |
Detectable BRAF mutation in serum DNA samples from patients with papillary thyroid carcinomas.
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pubmed:affiliation |
Department of Otolaryngology Head and Neck Surgery, Division of Head and Neck Cancer Research, Johns Hopkins Medical Institutions, Baltimore, MD 21287-0910, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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