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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2009-9-25
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pubmed:abstractText |
The persistence of circulating tumor cells (CTC) in breast cancer patients might be associated with stem cell like tumor cells which have been suggested to be the active source of metastatic spread in primary tumors. Furthermore, these cells also may undergo phenotypic changes, known as epithelial-mesenchymal transition (EMT), which allows them to travel to the site of metastasis formation without getting affected by conventional treatment. Here we evaluated 226 blood samples of 39 metastatic breast cancer patients during a follow-up of palliative chemo-, antibody - or hormonal therapy for the expression of the stem cell marker ALDH1 and markers for EMT and correlated these findings with the presence of CTC and response to therapy.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19589136-10623696,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19589136-11282020,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19589136-11410494,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19589136-12189386,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19589136-12604184,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19589136-12657737,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19589136-14680486,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19589136-15151202,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19589136-15254419,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19589136-15294153,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19589136-15328170,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19589136-15709183,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19589136-16120859,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19589136-16319975,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19589136-16782806,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19589136-17020960,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19589136-17020963,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19589136-17217540,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19589136-17229949,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19589136-17332325,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19589136-17349583,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19589136-17537911,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19589136-17785550,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19589136-17873341,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19589136-17963511,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19589136-18167340,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19589136-18371393,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19589136-18404148,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19589136-18544962,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19589136-18679793,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19589136-18784658,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19589136-18793387,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19589136-18822183
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Aldehyde Dehydrogenase,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD34,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation,
http://linkedlifedata.com/resource/pubmed/chemical/Biological Markers,
http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Retinal Dehydrogenase,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Markers, Biological,
http://linkedlifedata.com/resource/pubmed/chemical/aldehyde dehydrogenase 1
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pubmed:status |
MEDLINE
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pubmed:issn |
1465-542X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
R46
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:19589136-Adult,
pubmed-meshheading:19589136-Aged,
pubmed-meshheading:19589136-Aldehyde Dehydrogenase,
pubmed-meshheading:19589136-Antigens, CD34,
pubmed-meshheading:19589136-Antigens, Differentiation,
pubmed-meshheading:19589136-Biological Markers,
pubmed-meshheading:19589136-Breast Neoplasms,
pubmed-meshheading:19589136-Carcinoma, Ductal, Breast,
pubmed-meshheading:19589136-Cell Line, Tumor,
pubmed-meshheading:19589136-Cell Transdifferentiation,
pubmed-meshheading:19589136-Epithelial Cells,
pubmed-meshheading:19589136-Female,
pubmed-meshheading:19589136-Humans,
pubmed-meshheading:19589136-Isoenzymes,
pubmed-meshheading:19589136-Mesoderm,
pubmed-meshheading:19589136-Middle Aged,
pubmed-meshheading:19589136-Neoplasm Proteins,
pubmed-meshheading:19589136-Neoplastic Cells, Circulating,
pubmed-meshheading:19589136-Neoplastic Stem Cells,
pubmed-meshheading:19589136-Ovarian Neoplasms,
pubmed-meshheading:19589136-Retinal Dehydrogenase,
pubmed-meshheading:19589136-Tumor Markers, Biological,
pubmed-meshheading:19589136-Young Adult
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pubmed:year |
2009
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pubmed:articleTitle |
Stem cell and epithelial-mesenchymal transition markers are frequently overexpressed in circulating tumor cells of metastatic breast cancer patients.
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pubmed:affiliation |
Department of Gynecology and Obstetrics, University Hospital Essen, University of Duisburg-Essen, Hufelandstrasse 55, 45122 Essen, Germany. bahriye.aktas@uk-essen.de
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pubmed:publicationType |
Journal Article
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