epithelial to mesenchymal transition

Source:http://linkedlifedata.com/resource/umls/id/C1523298

GO: A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. [GOC:dph, PMID:14701881],GO: A transition where a mesenchymal cell establishes apical/basolateral polarity, forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell. [GOC:ascb_2009, GOC:dph, GOC:tb],MSH: Phenotypic changes of EPITHELIAL CELLS to MESENCHYME type, which increase cell mobility critical in many developmental processes such as NEURAL TUBE development. NEOPLASM METASTASIS and DISEASE PROGRESSION may also induce this transition.,NCI: A cellular process where an epithelial cell loses polarity, disassembles adhesive junctions, degrades its basement membrane and transforms into a migratory mesenchymal cell.

Download in:

View as