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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2009-6-18
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pubmed:abstractText |
Cell differentiation in developing tissues is controlled by a small set of signaling pathways, which must coordinate the timing and levels of activation to ensure robust and precise outcomes. Highly coordinated activation of signaling pathways can result from cross-regulatory interactions in multi-pathway networks. Here we explore the dynamics and function of pathway coordination between the EGFR and DPP pathways during Drosophila wing-vein differentiation. We show that simultaneous activation of both the EGFR and DPP pathways must be maintained for vein cell differentiation and that above-threshold ectopic activation of either pathway is sufficient to drive vein cell differentiation outside the proveins. The joint activation of the EGFR and DPP signaling systems is ensured by a positive feedback loop, in which the two pathways stimulate each other at the level of ligand production.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19536201-10331978,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19536201-10572049,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19536201-10952893,
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1744-4292
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
278
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pubmed:dateRevised |
2011-5-5
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pubmed:meshHeading |
pubmed-meshheading:19536201-Animals,
pubmed-meshheading:19536201-Cell Differentiation,
pubmed-meshheading:19536201-Drosophila,
pubmed-meshheading:19536201-Drosophila Proteins,
pubmed-meshheading:19536201-Feedback, Physiological,
pubmed-meshheading:19536201-Fluorescent Antibody Technique,
pubmed-meshheading:19536201-Receptor, Epidermal Growth Factor,
pubmed-meshheading:19536201-Receptors, Invertebrate Peptide,
pubmed-meshheading:19536201-Signal Transduction,
pubmed-meshheading:19536201-Wing
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pubmed:year |
2009
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pubmed:articleTitle |
Bistability coordinates activation of the EGFR and DPP pathways in Drosophila vein differentiation.
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pubmed:affiliation |
Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY 14642, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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