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pubmed-article:19529947pubmed:abstractTextHypoxia-inducible factor 1 (HIF-1) is a hypoxia-induced transcription factor that regulates gene expression in critical pathways involved in tumour growth and metastasis. Metallothionein (MT) is a group of small molecular weight cysteine-rich proteins with a broad variety of functions. The present study aimed to analyse the prognostic impact of HIF-1alpha and MT expression in colorectal cancer and to evaluate a possible link of combined HIF-1alpha and MT expression with colorectal cancer progression.lld:pubmed
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pubmed-article:19529947pubmed:articleTitleCombined analysis of hypoxia-inducible factor 1 alpha and metallothionein indicates an aggressive subtype of colorectal carcinoma.lld:pubmed
pubmed-article:19529947pubmed:affiliationInstitute of Pathology and Neuropathology, University Hospital Essen, University of Duisburg-Essen, Hufelandstr. 55, 45122 Essen, Germany. klaus.schmitz@uni-duisburg-essen.delld:pubmed
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