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rdf:type |
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lifeskim:mentions |
umls-concept:C0009402,
umls-concept:C0025545,
umls-concept:C0205195,
umls-concept:C0215848,
umls-concept:C0449560,
umls-concept:C0580822,
umls-concept:C0936012,
umls-concept:C1547300,
umls-concept:C1548760,
umls-concept:C1550594,
umls-concept:C2003941
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pubmed:issue |
11
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pubmed:dateCreated |
2009-10-7
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pubmed:abstractText |
Hypoxia-inducible factor 1 (HIF-1) is a hypoxia-induced transcription factor that regulates gene expression in critical pathways involved in tumour growth and metastasis. Metallothionein (MT) is a group of small molecular weight cysteine-rich proteins with a broad variety of functions. The present study aimed to analyse the prognostic impact of HIF-1alpha and MT expression in colorectal cancer and to evaluate a possible link of combined HIF-1alpha and MT expression with colorectal cancer progression.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1432-1262
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
24
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1287-96
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:19529947-Amino Acids, Dicarboxylic,
pubmed-meshheading:19529947-Apoptosis,
pubmed-meshheading:19529947-Cell Line, Tumor,
pubmed-meshheading:19529947-Cell Proliferation,
pubmed-meshheading:19529947-Colorectal Neoplasms,
pubmed-meshheading:19529947-Epithelial Cells,
pubmed-meshheading:19529947-Female,
pubmed-meshheading:19529947-Humans,
pubmed-meshheading:19529947-Hypoxia-Inducible Factor 1, alpha Subunit,
pubmed-meshheading:19529947-Immunohistochemistry,
pubmed-meshheading:19529947-Kaplan-Meier Estimate,
pubmed-meshheading:19529947-Male,
pubmed-meshheading:19529947-Metallothionein,
pubmed-meshheading:19529947-Phenotype,
pubmed-meshheading:19529947-Reactive Oxygen Species,
pubmed-meshheading:19529947-Staining and Labeling
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pubmed:year |
2009
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pubmed:articleTitle |
Combined analysis of hypoxia-inducible factor 1 alpha and metallothionein indicates an aggressive subtype of colorectal carcinoma.
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pubmed:affiliation |
Institute of Pathology and Neuropathology, University Hospital Essen, University of Duisburg-Essen, Hufelandstr. 55, 45122 Essen, Germany. klaus.schmitz@uni-duisburg-essen.de
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pubmed:publicationType |
Journal Article
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