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Decellularized materials, which represent a popular option for a variety of applications in regenerative medicine, including bioprosthetic heart valves, offer the opportunity to study cellular responses to extracellular matrix biochemistry and architecture. The study aim was to investigate the response of U937 macrophage-like cells (a model of the monocyte-derived macrophage, the pivotal cell to the initial and chronic cellular responses to implanted biomaterials) to decellularized bovine pericardium, to explore its expected biological performance in vivo, and to predict any adverse reactions in clinical trials.
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