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rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
4
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pubmed:dateCreated |
2009-6-10
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|
pubmed:abstractText |
This review focuses on CD4+ T cells involved in the mediation of inflammatory tissue damage in murine models of inflammatory bowel diseases (IBDs). In particular, we describe the distinct roles of the homeostatic cytokine IL-7, which is essential to the maintenance of colitogenic memory CD4+ cells, and the newly discovered effector cytokine IL-17. We also discuss the close correlation between colitogenic Th17-type CD4+ T cells and inducible CD4+CD25+Foxp3+ regulatory T cells.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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|
pubmed:month |
Jul
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|
pubmed:issn |
1531-7056
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|
pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
25
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pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
306-13
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pubmed:meshHeading |
pubmed-meshheading:19448533-Animals,
pubmed-meshheading:19448533-Cohort Studies,
pubmed-meshheading:19448533-Cytokines,
pubmed-meshheading:19448533-Disease Models, Animal,
pubmed-meshheading:19448533-Drug Delivery Systems,
pubmed-meshheading:19448533-Homeostasis,
pubmed-meshheading:19448533-Immunologic Memory,
pubmed-meshheading:19448533-Immunosuppressive Agents,
pubmed-meshheading:19448533-Inflammatory Bowel Diseases,
pubmed-meshheading:19448533-Interleukin-17,
pubmed-meshheading:19448533-Interleukin-7,
pubmed-meshheading:19448533-Mice,
pubmed-meshheading:19448533-Mice, Inbred BALB C,
pubmed-meshheading:19448533-Mice, SCID,
pubmed-meshheading:19448533-Sensitivity and Specificity,
pubmed-meshheading:19448533-T-Lymphocytes, Helper-Inducer,
pubmed-meshheading:19448533-T-Lymphocytes, Regulatory
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pubmed:year |
2009
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pubmed:articleTitle |
Homeostatic (IL-7) and effector (IL-17) cytokines as distinct but complementary target for an optimal therapeutic strategy in inflammatory bowel disease.
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|
pubmed:affiliation |
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan. takagast@sc.itc.keio.ac.jp
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pubmed:publicationType |
Journal Article,
Review
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