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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
30
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pubmed:dateCreated |
2009-6-8
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pubmed:abstractText |
Studying the mechanisms of host survival resulting from viral encephalitis is critical to the development of vaccines. Here we have shown in several independent studies that high dose treatment with neutralizing antibody prior to intranasal infection with Venezuelan equine encephalitis virus had an antiviral effect in the visceral organs and prolonged survival time of infected mice, even in the absence of alphabeta T cells. Nevertheless, antibody treatment did not prevent the development of lethal encephalitis. On the contrary, the adoptive transfer of primed CD4(+) T cells was necessary to prevent lethal encephalitis in mice lacking alphabeta T cell receptor.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19446933-10196323,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19446933-10729167,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19446933-11858855,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19446933-12161021,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19446933-12466850,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19446933-12915543,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19446933-1359428,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19446933-14563324,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19446933-14651460,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19446933-15694514,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19446933-16237062,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19446933-16358422,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19446933-16501087,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19446933-16549790,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19446933-17426186,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19446933-17610927,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19446933-1841630,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19446933-1901381,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19446933-3184276,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19446933-4578265,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19446933-7676619,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19446933-7747437,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19446933-8411346,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19446933-8572944,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19446933-8709783,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19446933-9123821,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19446933-9196217,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19446933-9416509
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1873-2518
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pubmed:author |
pubmed-author:BertkeAndrea SAS,
pubmed-author:BorisevichViktoriyaV,
pubmed-author:EstesD MarkDM,
pubmed-author:JudyBarbara MBM,
pubmed-author:PaesslerSlobodanS,
pubmed-author:PengBi-HungBH,
pubmed-author:PoussardAllison LAL,
pubmed-author:SalazarMilagrosM,
pubmed-author:SmithJeanon NJN,
pubmed-author:SmithJennifer KJK,
pubmed-author:YunNadezhda ENE,
pubmed-author:ZacksMichele AMA
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pubmed:issnType |
Electronic
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pubmed:day |
19
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pubmed:volume |
27
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4064-73
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pubmed:dateRevised |
2010-9-27
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pubmed:meshHeading |
pubmed-meshheading:19446933-Adoptive Transfer,
pubmed-meshheading:19446933-Animals,
pubmed-meshheading:19446933-Antibodies, Viral,
pubmed-meshheading:19446933-CD4-Positive T-Lymphocytes,
pubmed-meshheading:19446933-Encephalitis Virus, Venezuelan Equine,
pubmed-meshheading:19446933-Encephalomyelitis, Venezuelan Equine,
pubmed-meshheading:19446933-Female,
pubmed-meshheading:19446933-Male,
pubmed-meshheading:19446933-Mice,
pubmed-meshheading:19446933-Mice, Inbred C57BL,
pubmed-meshheading:19446933-Mice, Knockout,
pubmed-meshheading:19446933-Neutralization Tests,
pubmed-meshheading:19446933-Receptors, Antigen, T-Cell,
pubmed-meshheading:19446933-Survival Analysis
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pubmed:year |
2009
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pubmed:articleTitle |
CD4+ T cells provide protection against acute lethal encephalitis caused by Venezuelan equine encephalitis virus.
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pubmed:affiliation |
Department of Pathology, Galveston National Laboratory and Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX 77555-0609, United States.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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