Linked Life Data

19369057

Source:http://linkedlifedata.com/resource/pubmed/id/19369057

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2010-3-15
pubmed:abstractText
Placebo-controlled clinical studies suggest that intake of n-3 polyunsaturated fatty acids improves neurological disorders such as Alzheimer's disease, Huntington's disease and schizophrenia. To evaluate the impact of eicosapentaenoic acid (EPA), we orally administered highly purified ethyl EPA (EPA-E) to rats at a dose of 1.0 mg/g per day and measured long-term potentiation of the CA1 hippocampal region, a physiological correlate of synaptic plasticity that is thought to underlie learning and memory. The mean field excitatory postsynaptic potential slope of the EPA-E group was significantly greater than that of the control group in the CA1 region. Gene expression of hippocampal p85alpha, one of the regulatory subunits of phosphatidylinositol 3-kinase (PI3-kinase), was increased with EPA-E administration. Investigation of fatty acid profiles of neuronal and glia-enriched fractions demonstrated that a single administration of EPA-E significantly increased neuronal and glial EPA content and glial docosahexaenoic acid content, clearly suggesting that EPA was indeed taken up by both neurons and glial cells. In addition, we investigated the direct effects of EPA on the PI3-kinase/Akt pathway in differentiated PC12 cells. Phosphorylated-Akt expression was significantly increased in EPA-treated cells, and nerve growth factor withdrawal-induced increases in cell death and caspase-3 activity were suppressed by EPA treatment. These findings suggest that EPA protects against neurodegeneration by modulating synaptic plasticity and activating the PI3-kinase/Akt pathway, possibly by its own functional effects in neurons and glial cells and by its capacity to increase brain docosahexaenoic acid.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1873-4847
pubmed:author
pubmed:copyrightInfo
Copyright 2010 Elsevier Inc. All rights reserved.
pubmed:issnType
Electronic
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
268-77
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed-meshheading:19369057-Animals, pubmed-meshheading:19369057-Brain, pubmed-meshheading:19369057-CA1 Region, Hippocampal, pubmed-meshheading:19369057-Cell Death, pubmed-meshheading:19369057-Cell Differentiation, pubmed-meshheading:19369057-Dietary Fats, pubmed-meshheading:19369057-Eicosapentaenoic Acid, pubmed-meshheading:19369057-Fatty Acids, pubmed-meshheading:19369057-Gene Expression Regulation, Enzymologic, pubmed-meshheading:19369057-Hippocampus, pubmed-meshheading:19369057-Long-Term Potentiation, pubmed-meshheading:19369057-Male, pubmed-meshheading:19369057-Neuroglia, pubmed-meshheading:19369057-Neuronal Plasticity, pubmed-meshheading:19369057-Neurons, pubmed-meshheading:19369057-PC12 Cells, pubmed-meshheading:19369057-Phosphatidylinositol 3-Kinases, pubmed-meshheading:19369057-Proto-Oncogene Proteins c-akt, pubmed-meshheading:19369057-RNA, Messenger, pubmed-meshheading:19369057-Random Allocation, pubmed-meshheading:19369057-Rats, pubmed-meshheading:19369057-Rats, Wistar, pubmed-meshheading:19369057-Signal Transduction
pubmed:year
2010
pubmed:articleTitle
Effects of eicosapentaenoic acid on synaptic plasticity, fatty acid profile and phosphoinositide 3-kinase signaling in rat hippocampus and differentiated PC12 cells.
pubmed:affiliation
Development Research, Pharmaceutical Research Center, Mochida Pharmaceutical Company Limited, Jimba, Gotemba, Shizuoka 412-8524, Japan.
pubmed:publicationType
Journal Article, In Vitro