| pubmed-article:1928306 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1928306 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:1928306 | lifeskim:mentions | umls-concept:C0225336 | lld:lifeskim |
| pubmed-article:1928306 | lifeskim:mentions | umls-concept:C0041637 | lld:lifeskim |
| pubmed-article:1928306 | lifeskim:mentions | umls-concept:C1704628 | lld:lifeskim |
| pubmed-article:1928306 | lifeskim:mentions | umls-concept:C0030190 | lld:lifeskim |
| pubmed-article:1928306 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:1928306 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:1928306 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:1928306 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:1928306 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:1928306 | pubmed:dateCreated | 1991-11-19 | lld:pubmed |
| pubmed-article:1928306 | pubmed:abstractText | The effect of exposure to hyperthermia on the fibrinolytic potential of human umbilical vein endothelial cells (HUVEC) in culture was studied. HUVEC responded to exposure to 42 degrees C with a time-dependent increase in plasminogen activator inhibitor type 1 (PAI-1) activity and antigen accompanied by a four- to fivefold increase in PAI-1 specific m-RNA and a decrease in tissue-type plasminogen activator (t-PA) antigen. The effect of 8 hours exposure to hyperthermia on PAI-1 activity and antigen could not be reversed by reexposure of the cells to 37 degrees C for 24 hours as evidenced by continuously increased amounts of PAI-1 released into the conditioned media. t-PA release, however, decreased during the 24-hour period at 37 degrees C after exposure to hyperthermia. No difference in PAI-1 antigen present in the extracellular matrix of heat treated HUVEC as compared to HUVEC kept at 37 degrees C could be found. Our data supports the idea that hyperthermia is one stress factor that influences the fibrinolytic potential of endothelial cells. | lld:pubmed |
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| pubmed-article:1928306 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1928306 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1928306 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:1928306 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1928306 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:1928306 | pubmed:issn | 0002-9440 | lld:pubmed |
| pubmed-article:1928306 | pubmed:author | pubmed-author:BinderB RBR | lld:pubmed |
| pubmed-article:1928306 | pubmed:author | pubmed-author:ChristGG | lld:pubmed |
| pubmed-article:1928306 | pubmed:author | pubmed-author:HooverR LRL | lld:pubmed |
| pubmed-article:1928306 | pubmed:author | pubmed-author:WojtaJJ | lld:pubmed |
| pubmed-article:1928306 | pubmed:author | pubmed-author:HolzerMM | lld:pubmed |
| pubmed-article:1928306 | pubmed:author | pubmed-author:HufnaglPP | lld:pubmed |
| pubmed-article:1928306 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1928306 | pubmed:volume | 139 | lld:pubmed |
| pubmed-article:1928306 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1928306 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1928306 | pubmed:pagination | 911-9 | lld:pubmed |
| pubmed-article:1928306 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:1928306 | pubmed:meshHeading | pubmed-meshheading:1928306-... | lld:pubmed |
| pubmed-article:1928306 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1928306 | pubmed:articleTitle | Hyperthermia stimulates plasminogen activator inhibitor type 1 expression in human umbilical vein endothelial cells in vitro. | lld:pubmed |
| pubmed-article:1928306 | pubmed:affiliation | Laboratory for Clinical Experimental Physiology, University of Vienna, Austria. | lld:pubmed |
| pubmed-article:1928306 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1928306 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:1928306 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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