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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1991-11-19
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pubmed:abstractText |
The effect of exposure to hyperthermia on the fibrinolytic potential of human umbilical vein endothelial cells (HUVEC) in culture was studied. HUVEC responded to exposure to 42 degrees C with a time-dependent increase in plasminogen activator inhibitor type 1 (PAI-1) activity and antigen accompanied by a four- to fivefold increase in PAI-1 specific m-RNA and a decrease in tissue-type plasminogen activator (t-PA) antigen. The effect of 8 hours exposure to hyperthermia on PAI-1 activity and antigen could not be reversed by reexposure of the cells to 37 degrees C for 24 hours as evidenced by continuously increased amounts of PAI-1 released into the conditioned media. t-PA release, however, decreased during the 24-hour period at 37 degrees C after exposure to hyperthermia. No difference in PAI-1 antigen present in the extracellular matrix of heat treated HUVEC as compared to HUVEC kept at 37 degrees C could be found. Our data supports the idea that hyperthermia is one stress factor that influences the fibrinolytic potential of endothelial cells.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1928306-110462,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1928306-1168187,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1928306-1697297,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1928306-174237,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1928306-2430793,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1928306-2440339,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1928306-2453896,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1928306-2467379,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1928306-2501899,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1928306-3088564,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1928306-3108431,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1928306-3121634,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1928306-3128548,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1928306-3148525,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1928306-3148526,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1928306-3259442,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1928306-3279055,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1928306-3490474,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1928306-3498518,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1928306-3540146,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1928306-3920245,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1928306-4363161,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1928306-4583980,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1928306-6213638,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1928306-6312838,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1928306-6329026,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1928306-6438154,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1928306-6467226,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1928306-7236661
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0002-9440
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
139
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
911-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:1928306-Blotting, Northern,
pubmed-meshheading:1928306-Cells, Cultured,
pubmed-meshheading:1928306-Endothelium, Vascular,
pubmed-meshheading:1928306-Extracellular Matrix,
pubmed-meshheading:1928306-Fever,
pubmed-meshheading:1928306-Fibrinolysis,
pubmed-meshheading:1928306-Gene Expression,
pubmed-meshheading:1928306-Humans,
pubmed-meshheading:1928306-Membrane Proteins,
pubmed-meshheading:1928306-RNA, Messenger,
pubmed-meshheading:1928306-Time Factors,
pubmed-meshheading:1928306-Umbilical Veins
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pubmed:year |
1991
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pubmed:articleTitle |
Hyperthermia stimulates plasminogen activator inhibitor type 1 expression in human umbilical vein endothelial cells in vitro.
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pubmed:affiliation |
Laboratory for Clinical Experimental Physiology, University of Vienna, Austria.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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