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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2009-3-13
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pubmed:abstractText |
The dual Pd/proline-catalyzed alpha-allylation reaction of a variety of enolizable ketones and aldehydes with allylic alcohols is described. In this reaction, the choice of a large-bite angle ligand Xantphos and proline as the organocatalyst was essential for generation of the crucial pi-allyl Pd intermediate from allylic alcohol, followed by nucleophilic attack of the enamine formed in situ from the corresponding enolizable carbonyl substrate and proline.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1523-7052
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
19
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1453-6
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pubmed:meshHeading |
pubmed-meshheading:19243116-Aldehydes,
pubmed-meshheading:19243116-Alkylation,
pubmed-meshheading:19243116-Catalysis,
pubmed-meshheading:19243116-Combinatorial Chemistry Techniques,
pubmed-meshheading:19243116-Ketones,
pubmed-meshheading:19243116-Molecular Structure,
pubmed-meshheading:19243116-Palladium,
pubmed-meshheading:19243116-Phosphines,
pubmed-meshheading:19243116-Proline,
pubmed-meshheading:19243116-Propanols,
pubmed-meshheading:19243116-Stereoisomerism,
pubmed-meshheading:19243116-Xanthenes
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pubmed:year |
2009
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pubmed:articleTitle |
Dual palladium- and proline-catalyzed allylic alkylation of enolizable ketones and aldehydes with allylic alcohols.
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pubmed:affiliation |
Institut für Organische Chemie and Biochemie, Freiburg Institute for Advanced Studies, Albert-Ludwigs-Universität Freiburg, Albertstrasse 21, 79104 Freiburg, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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