| pubmed-article:19232403 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19232403 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:19232403 | lifeskim:mentions | umls-concept:C0596902 | lld:lifeskim |
| pubmed-article:19232403 | lifeskim:mentions | umls-concept:C1158883 | lld:lifeskim |
| pubmed-article:19232403 | pubmed:dateCreated | 2009-5-18 | lld:pubmed |
| pubmed-article:19232403 | pubmed:abstractText | The renal type II Na/Pi cotransporters, Na/Pi-IIa and Na/Pi-IIc, are expressed in the brush border membrane (BBM) of the renal proximal tubule cells. Because it has long been thought that Na/Pi-IIa alone can regulate the reabsorption of phosphate in the proximal renal tubules, Na/Pi-IIc has not been paid much attention by the renal research community. Recent studies, however, have identified Na/Pi-IIc mutations as the defective cause of hereditary hypophosphatemic rickets with hypercalciuria (HHRH). This finding indicates that Na/Pi-IIc has a rather important role in renal Pi reabsorption and bone mineralization, and that it may be a key determinant of plasma Pi concentrations in humans. Studies of Na/Pi-IIc mice indicate that Na/Pi-IIc is necessary for normal calcium homeostasis, but its role in the regulation of Pi metabolism and bone physiology may be different from that in HHRH patients. Of note, Na/Pi-IIc KO mice display abnormal vitamin D regulation without hypophosphatemia or hyperphosphaturia. Thus, Na/Pi-IIc may be involved in regulating renal vitamin D synthesis in the proximal tubular cells. The identification of proteins that interact with Na/Pi-IIc is an important area of future research. The physiologic roles of Na/Pi-IIa and Na/Pi-IIc require future elucidation. | lld:pubmed |
| pubmed-article:19232403 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19232403 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19232403 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19232403 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19232403 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19232403 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19232403 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19232403 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19232403 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19232403 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:19232403 | pubmed:issn | 1873-2763 | lld:pubmed |
| pubmed-article:19232403 | pubmed:author | pubmed-author:MiyamotoKen-i... | lld:pubmed |
| pubmed-article:19232403 | pubmed:author | pubmed-author:SegawaHirokoH | lld:pubmed |
| pubmed-article:19232403 | pubmed:author | pubmed-author:KanekoIchiroI | lld:pubmed |
| pubmed-article:19232403 | pubmed:author | pubmed-author:TomoeYukaY | lld:pubmed |
| pubmed-article:19232403 | pubmed:author | pubmed-author:AranamiFumito... | lld:pubmed |
| pubmed-article:19232403 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19232403 | pubmed:volume | 45 Suppl 1 | lld:pubmed |
| pubmed-article:19232403 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19232403 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19232403 | pubmed:pagination | S2-7 | lld:pubmed |
| pubmed-article:19232403 | pubmed:meshHeading | pubmed-meshheading:19232403... | lld:pubmed |
| pubmed-article:19232403 | pubmed:meshHeading | pubmed-meshheading:19232403... | lld:pubmed |
| pubmed-article:19232403 | pubmed:meshHeading | pubmed-meshheading:19232403... | lld:pubmed |
| pubmed-article:19232403 | pubmed:meshHeading | pubmed-meshheading:19232403... | lld:pubmed |
| pubmed-article:19232403 | pubmed:meshHeading | pubmed-meshheading:19232403... | lld:pubmed |
| pubmed-article:19232403 | pubmed:meshHeading | pubmed-meshheading:19232403... | lld:pubmed |
| pubmed-article:19232403 | pubmed:meshHeading | pubmed-meshheading:19232403... | lld:pubmed |
| pubmed-article:19232403 | pubmed:meshHeading | pubmed-meshheading:19232403... | lld:pubmed |
| pubmed-article:19232403 | pubmed:meshHeading | pubmed-meshheading:19232403... | lld:pubmed |
| pubmed-article:19232403 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19232403 | pubmed:articleTitle | The roles of Na/Pi-II transporters in phosphate metabolism. | lld:pubmed |
| pubmed-article:19232403 | pubmed:affiliation | Department of Molecular Nutrition, Institution of Health Biosciences, University of Tokushima Graduate School, Kuramoto-Cho 3, Tokushima 770-8503, Japan. segawa@nutr.med.tokushima-u.ac.jp | lld:pubmed |
| pubmed-article:19232403 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19232403 | pubmed:publicationType | Review | lld:pubmed |
| pubmed-article:19232403 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
