Source:http://linkedlifedata.com/resource/pubmed/id/19232403
Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:dateCreated |
2009-5-18
|
pubmed:abstractText |
The renal type II Na/Pi cotransporters, Na/Pi-IIa and Na/Pi-IIc, are expressed in the brush border membrane (BBM) of the renal proximal tubule cells. Because it has long been thought that Na/Pi-IIa alone can regulate the reabsorption of phosphate in the proximal renal tubules, Na/Pi-IIc has not been paid much attention by the renal research community. Recent studies, however, have identified Na/Pi-IIc mutations as the defective cause of hereditary hypophosphatemic rickets with hypercalciuria (HHRH). This finding indicates that Na/Pi-IIc has a rather important role in renal Pi reabsorption and bone mineralization, and that it may be a key determinant of plasma Pi concentrations in humans. Studies of Na/Pi-IIc mice indicate that Na/Pi-IIc is necessary for normal calcium homeostasis, but its role in the regulation of Pi metabolism and bone physiology may be different from that in HHRH patients. Of note, Na/Pi-IIc KO mice display abnormal vitamin D regulation without hypophosphatemia or hyperphosphaturia. Thus, Na/Pi-IIc may be involved in regulating renal vitamin D synthesis in the proximal tubular cells. The identification of proteins that interact with Na/Pi-IIc is an important area of future research. The physiologic roles of Na/Pi-IIa and Na/Pi-IIc require future elucidation.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Phosphates,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Sodium-Hydrogen Antiporter,
http://linkedlifedata.com/resource/pubmed/chemical/Sodium-Phosphate Cotransporter...,
http://linkedlifedata.com/resource/pubmed/chemical/sodium-hydrogen exchanger...
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jul
|
pubmed:issn |
1873-2763
|
pubmed:author | |
pubmed:issnType |
Electronic
|
pubmed:volume |
45 Suppl 1
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
S2-7
|
pubmed:meshHeading |
pubmed-meshheading:19232403-Animals,
pubmed-meshheading:19232403-Humans,
pubmed-meshheading:19232403-Hypercalciuria,
pubmed-meshheading:19232403-Hypophosphatemic Rickets, X-Linked Dominant,
pubmed-meshheading:19232403-Mutation,
pubmed-meshheading:19232403-Phosphates,
pubmed-meshheading:19232403-Phosphoproteins,
pubmed-meshheading:19232403-Sodium-Hydrogen Antiporter,
pubmed-meshheading:19232403-Sodium-Phosphate Cotransporter Proteins, Type II
|
pubmed:year |
2009
|
pubmed:articleTitle |
The roles of Na/Pi-II transporters in phosphate metabolism.
|
pubmed:affiliation |
Department of Molecular Nutrition, Institution of Health Biosciences, University of Tokushima Graduate School, Kuramoto-Cho 3, Tokushima 770-8503, Japan. segawa@nutr.med.tokushima-u.ac.jp
|
pubmed:publicationType |
Journal Article,
Review,
Research Support, Non-U.S. Gov't
|