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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0078056,
umls-concept:C0079633,
umls-concept:C0086418,
umls-concept:C0185117,
umls-concept:C0225336,
umls-concept:C0332157,
umls-concept:C0806140,
umls-concept:C0851285,
umls-concept:C0871261,
umls-concept:C1135918,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2911684,
umls-concept:C2911692
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pubmed:issue |
5
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pubmed:dateCreated |
2009-4-16
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pubmed:abstractText |
Interleukin-8 (IL-8) is a soluble human-specific chemokine implicated in the development of the chronic inflammatory disease atherosclerosis. Recently, we showed that atheroprone hemodynamics induced IL-8 secretion from endothelial cells (ECs) concurrent with increased EC/smooth muscle cell (SMC) VCAM-1 expression in a human hemodynamic coculture model. Despite an IL-8 association with inflammation, we show here that blocking IL-8 activity during atheroprone flow resulted in increased levels of EC/SMC VCAM-1 expression. We tested the hypothesis that IL-8 limits SMC VCAM-1 expression in response to inflammatory stimuli, either atheroprone flow or cytokine interleukin-1beta (IL-1beta) addition.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19229069-10227295,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19229069-10341839,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19229069-10417402,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19229069-10894810,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19229069-11678724,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19229069-11755926,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19229069-11935287,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19229069-12069927,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19229069-12392995,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19229069-12615956,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19229069-1378077,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19229069-1381398,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19229069-15016640,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19229069-15177267,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19229069-15458980,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19229069-15466704,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19229069-15489374,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19229069-1650387,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19229069-16601268,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19229069-16822944,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19229069-16894012,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19229069-17189320,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19229069-17303384,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19229069-17412346,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19229069-17913848,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19229069-18054358,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19229069-18276911,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19229069-19023090,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19229069-2189453,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19229069-2688092,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19229069-3091693,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19229069-3260265,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19229069-7688768,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19229069-7963103,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19229069-7989611,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19229069-8013067,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19229069-8825878,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19229069-9012738,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19229069-9125306
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1524-4636
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
29
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
725-31
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pubmed:dateRevised |
2011-1-31
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pubmed:meshHeading |
pubmed-meshheading:19229069-Atherosclerosis,
pubmed-meshheading:19229069-Cells, Cultured,
pubmed-meshheading:19229069-Coculture Techniques,
pubmed-meshheading:19229069-Coronary Vessels,
pubmed-meshheading:19229069-Endothelial Cells,
pubmed-meshheading:19229069-Humans,
pubmed-meshheading:19229069-Interleukin-8,
pubmed-meshheading:19229069-Myocytes, Smooth Muscle,
pubmed-meshheading:19229069-Tunica Intima,
pubmed-meshheading:19229069-Umbilical Veins,
pubmed-meshheading:19229069-Vascular Cell Adhesion Molecule-1
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pubmed:year |
2009
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pubmed:articleTitle |
Human IL-8 regulates smooth muscle cell VCAM-1 expression in response to endothelial cells exposed to atheroprone flow.
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pubmed:affiliation |
Department of Biomedical Engineering, University of Virginia, Charlottesville, VA 22908, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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