19190755

Source:http://linkedlifedata.com/resource/pubmed/id/19190755

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0023884, umls-concept:C0040690, umls-concept:C0121463, umls-concept:C0333051, umls-concept:C0871261, umls-concept:C1519692, umls-concept:C1523298, umls-concept:C1704632, umls-concept:C1706817, umls-concept:C2911692
pubmed:issue	2
pubmed:dateCreated	2009-2-4
pubmed:abstractText	Chronic hepatitis C virus (HCV) infection and associated liver cirrhosis represent a major risk factor for hepatocellular carcinoma (HCC) development. TGF-beta is an important driver of liver fibrogenesis and cancer; however, its actual impact in human cancer progression is still poorly known. The aim of this study was to investigate the role of HCC-derived HCV core natural variants on cancer progression through their impact on TGF-beta signaling.
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pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/101285081
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Mutant Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Smad3 Protein, http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta, http://linkedlifedata.com/resource/pubmed/chemical/Viral Core Proteins, http://linkedlifedata.com/resource/pubmed/chemical/nucleocapsid protein, Hepatitis C...
pubmed:status	MEDLINE
pubmed:issn	1932-6203
pubmed:author	pubmed-author:AtfiAzeddineA, pubmed-author:BattagliaSerenaS, pubmed-author:BenzoubirNassimaN, pubmed-author:BourgeadeMarie-FrançoiseMF, pubmed-author:BréchotChristianC, pubmed-author:CharneauPierreP, pubmed-author:NobiletSoizicS, pubmed-author:SamuelDidierD, pubmed-author:ZignegoAnna LindaAL
pubmed:issnType	Electronic
pubmed:volume	4
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	e4355
pubmed:dateRevised	2009-11-18
pubmed:meshHeading	pubmed-meshheading:19190755-Animals, pubmed-meshheading:19190755-Cell Death, pubmed-meshheading:19190755-Cell Line, Tumor, pubmed-meshheading:19190755-Cell Proliferation, pubmed-meshheading:19190755-Epithelium, pubmed-meshheading:19190755-Hepatocytes, pubmed-meshheading:19190755-Humans, pubmed-meshheading:19190755-Liver Neoplasms, pubmed-meshheading:19190755-Mesoderm, pubmed-meshheading:19190755-Mice, pubmed-meshheading:19190755-Mutant Proteins, pubmed-meshheading:19190755-Smad3 Protein, pubmed-meshheading:19190755-Transforming Growth Factor beta, pubmed-meshheading:19190755-Viral Core Proteins
pubmed:year	2009
pubmed:articleTitle	Liver cancer-derived hepatitis C virus core proteins shift TGF-beta responses from tumor suppression to epithelial-mesenchymal transition.

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