Source:http://linkedlifedata.com/resource/pubmed/id/19057841
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
2008-12-26
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pubmed:abstractText |
Multiple myeloma (MM) cell adhesion to stromal cells via very late antigen (VLA)-4 and vascular cell adhesion molecule (VCAM)-1 interaction causes enhanced secretion of osteoclastogenic activity by MM cells. We have reported that MM cell-derived macrophage inflammatory protein (MIP)-1alpha and MIP-1beta are responsible for most of the osteoclastogenic activity in MM. Thus, adhesion-mediated osteoclastogenesis may be caused by enhanced production of MIP-1 via VLA-4-VCAM-1 interaction. The present study was undertaken to clarify whether MM cell-derived MIP-1 plays a role in VLA-4-VCAM-1 adhesion-mediated osteoclastogenesis. Adhesion of MM cells to VCAM-1 upregulated MIP-1alpha and MIP-1beta production from MM cells and enhanced production of osteoclastogenic activity by MM cells. Blockade of MIP-1alpha and MIP-1beta actions not only abrogated elaboration of osteoclastogenic activity, but also suppressed spontaneous MM cell adhesion to VCAM-1. These results demonstrate that MM cell adhesion to VCAM-1 upregulates MIP-1 production by MM cells to cause enhancement of osteoclastogenesis. In addition, the results suggest that the increased production of MIP-1 further enhances MM cell binding to stromal cells via stimulation of VLA-4-VCAM-1 adhesion, forming a "vicious cycle" between MM cell adhesion to stromal cells and MIP-1 production via VLA-4-VCAM-1 interaction.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0914-8779
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
27
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
16-23
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pubmed:meshHeading |
pubmed-meshheading:19057841-Animals,
pubmed-meshheading:19057841-Bone Marrow Cells,
pubmed-meshheading:19057841-Cell Adhesion,
pubmed-meshheading:19057841-Cell Line,
pubmed-meshheading:19057841-Chemokine CCL3,
pubmed-meshheading:19057841-Chemokine CCL4,
pubmed-meshheading:19057841-Humans,
pubmed-meshheading:19057841-Integrin alpha4beta1,
pubmed-meshheading:19057841-Mice,
pubmed-meshheading:19057841-Multiple Myeloma,
pubmed-meshheading:19057841-Osteoclasts,
pubmed-meshheading:19057841-Stromal Cells,
pubmed-meshheading:19057841-Vascular Cell Adhesion Molecule-1
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pubmed:year |
2009
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pubmed:articleTitle |
Vicious cycle between myeloma cell binding to bone marrow stromal cells via VLA-4-VCAM-1 adhesion and macrophage inflammatory protein-1alpha and MIP-1beta production.
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pubmed:affiliation |
Department of Medicine and Bioregulatory Sciences, University of Tokushima Graduate School of Medical Sciences, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan. masabe@clin.med.tokushima-u.ac.jp
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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