Linked Life Data

19022749

Source:http://linkedlifedata.com/resource/pubmed/id/19022749

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2009-5-29
pubmed:abstractText
The Drosophila ovary contains at least three types of active stem cells, namely, germ-line stem cells (GSCs), escort stem cells (ESCs), and follicular stem cells (FSCs), which work together to efficiently assemble egg chambers. Among the three stem cell types, the GSC is among the first shown to be controlled by the niche due to its easy identification and welldefined surrounding cells. We have shown that the niche controls GSC self-renewal, anchorage, aging, and competition, and the GSC also signals back to the niche for its maintenance. The FSC is an attractive model for studying epithelial stem cell regulation and signal integration because we have shown that it resembles mammalian epithelial stem cells and requires multiple signaling pathways for its self-renewal. In this chapter, we have highlighted the findings of our studies on interactions between Drosophila ovarian stem cells and their niches during normal development and aging and on stem cell competition for niche occupancy. We further discuss their implications in general stem cell biology and future directions in this exciting area.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1943-4456
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
73
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
39-47
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Interactions between stem cells and their niche in the Drosophila ovary.
pubmed:affiliation
Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural