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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2009-3-17
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pubmed:abstractText |
TNFerade is a radioinducible adenoviral vector expressing tumor necrosis factor-alpha (TNF-alpha) (Ad.Egr-TNF) currently in a phase III trial for inoperable pancreatic cancer. We studied B16-F1 melanoma tumors in TNF receptor wild-type (C57BL/6) and deficient (TNFR1,2-/- and TNFR1-/-) mice. Ad.Egr-TNF+IR inhibited tumor growth compared with IR in C57BL/6 but not in receptor-deficient mice. Tumors resistant to TNF-alpha were also sensitive to Ad.Egr-TNF+IR in C57BL/6 mice. Ad.Egr-TNF+IR produced an increase in tumor-associated endothelial cell apoptosis not observed in receptor-deficient animals. Also, B16-F1 tumors in mice with germline deletions of TNFR1,2, TNFR1 or TNF-alpha, or in mice receiving anti-TNF-alpha exhibited radiosensitivity. These results show that tumor-associated endothelium is the principal target for Ad.Egr-TNF radiosensitization and implicate TNF-alpha signaling in tumor radiosensitivity.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin G,
http://linkedlifedata.com/resource/pubmed/chemical/Immunosuppressive Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Radiation-Sensitizing Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Tumor Necrosis Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Tumor Necrosis Factor...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Tumor Necrosis Factor...,
http://linkedlifedata.com/resource/pubmed/chemical/TNFR-Fc fusion protein,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1476-5500
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pubmed:author |
pubmed-author:BeckettM AMA,
pubmed-author:DargeHH,
pubmed-author:EfimovaEE,
pubmed-author:GalkaEE,
pubmed-author:HellmanSS,
pubmed-author:KhodarevN NNN,
pubmed-author:KingC RCR,
pubmed-author:KufeD WDW,
pubmed-author:LiangHH,
pubmed-author:MauceriH JHJ,
pubmed-author:PitrodaSS,
pubmed-author:PosnerM CMC,
pubmed-author:SuttonH GHG,
pubmed-author:WeichselbaumR RRR
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pubmed:issnType |
Electronic
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
373-81
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pubmed:meshHeading |
pubmed-meshheading:18974777-Animals,
pubmed-meshheading:18974777-Apoptosis,
pubmed-meshheading:18974777-Cell Line, Tumor,
pubmed-meshheading:18974777-Endothelial Cells,
pubmed-meshheading:18974777-Gene Therapy,
pubmed-meshheading:18974777-Humans,
pubmed-meshheading:18974777-Immunoglobulin G,
pubmed-meshheading:18974777-Immunosuppressive Agents,
pubmed-meshheading:18974777-Melanoma, Experimental,
pubmed-meshheading:18974777-Mice,
pubmed-meshheading:18974777-Neoplasm Transplantation,
pubmed-meshheading:18974777-Radiation-Sensitizing Agents,
pubmed-meshheading:18974777-Receptors, Tumor Necrosis Factor,
pubmed-meshheading:18974777-Receptors, Tumor Necrosis Factor, Type I,
pubmed-meshheading:18974777-Receptors, Tumor Necrosis Factor, Type II,
pubmed-meshheading:18974777-Tumor Necrosis Factor-alpha,
pubmed-meshheading:18974777-X-Ray Therapy
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pubmed:year |
2009
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pubmed:articleTitle |
Translational strategies exploiting TNF-alpha that sensitize tumors to radiation therapy.
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pubmed:affiliation |
Department of Radiation and Cellular Oncology, The University of Chicago, Chicago, IL, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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