|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0003595,
umls-concept:C0017262,
umls-concept:C0022646,
umls-concept:C0025545,
umls-concept:C0025936,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0086860,
umls-concept:C0185117,
umls-concept:C0205054,
umls-concept:C2587213,
umls-concept:C2911684
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
1991-10-9
|
|
pubmed:abstractText |
We created three lines of transgenic mice with an integrated rat genomic apolipoprotein E gene fused with the mouse metallothionein I promoter. These lines transcribed rat apoE mRNA in the liver and/or in the kidney and expressed significant amounts of rat apoE in plasma. Enhancement of the plasma level by treatment with Zn ion or Bi ion was observed.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Aug
|
|
pubmed:issn |
0006-3002
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
27
|
|
pubmed:volume |
1090
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
91-4
|
|
pubmed:dateRevised |
2008-11-21
|
|
pubmed:meshHeading |
pubmed-meshheading:1883846-Animals,
pubmed-meshheading:1883846-Apolipoproteins E,
pubmed-meshheading:1883846-Base Sequence,
pubmed-meshheading:1883846-Bismuth,
pubmed-meshheading:1883846-Blotting, Northern,
pubmed-meshheading:1883846-Blotting, Southern,
pubmed-meshheading:1883846-Gene Expression Regulation,
pubmed-meshheading:1883846-Immunoblotting,
pubmed-meshheading:1883846-Kidney,
pubmed-meshheading:1883846-Liver,
pubmed-meshheading:1883846-Metallothionein,
pubmed-meshheading:1883846-Mice,
pubmed-meshheading:1883846-Mice, Transgenic,
pubmed-meshheading:1883846-Molecular Sequence Data,
pubmed-meshheading:1883846-Promoter Regions, Genetic,
pubmed-meshheading:1883846-Rats,
pubmed-meshheading:1883846-Recombinant Proteins,
pubmed-meshheading:1883846-Zinc
|
|
pubmed:year |
1991
|
|
pubmed:articleTitle |
Hepatic and renal expression of rat apolipoprotein E under control of the metallothionein promoter in transgenic mice.
|
|
pubmed:affiliation |
Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan.
|
|
pubmed:publicationType |
Journal Article
|
