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rdf:type |
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lifeskim:mentions |
umls-concept:C0003737,
umls-concept:C0037083,
umls-concept:C0059239,
umls-concept:C0063510,
umls-concept:C1547706,
umls-concept:C1565434,
umls-concept:C1710082,
umls-concept:C1880355,
umls-concept:C1880371,
umls-concept:C1882071,
umls-concept:C1999269,
umls-concept:C2347609
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pubmed:issue |
21
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pubmed:dateCreated |
2008-10-22
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pubmed:abstractText |
Inspired by bioactive indoline alkaloid natural products, here, we report a divergent synthesis approach that led to skeletally diverse indoline alkaloid-inspired compounds. The natural product-inspired compounds obtained were then subjected to a series of in vitro and cellular assays to examine their properties as modulators of focal adhesion kinase (FAK) activity. This study resulted in the identification of a promising lead inhibitor of FAK (42), which also showed activity in a wound healing and cell invasion assay. The in silico study of the lead compound (42) was also undertaken.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1464-3391
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pubmed:author |
pubmed-author:Alaoui-JamaliMoulayM,
pubmed-author:AryaPrabhatP,
pubmed-author:BarnesMichael LML,
pubmed-author:BijianKrikorK,
pubmed-author:Campagna-SlaterValérieV,
pubmed-author:JosephReniR,
pubmed-author:LeekDonald MDM,
pubmed-author:LougheedCarolineC,
pubmed-author:PoondraRajamohan RRR,
pubmed-author:PrakeschMichaelM,
pubmed-author:QuevillonSophieS,
pubmed-author:ReayiAyubA,
pubmed-author:SchapiraMatthieuM,
pubmed-author:SesmiloEstherE,
pubmed-author:WeiChang-QingCQ,
pubmed-author:XuBinB
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
9596-602
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:18835181-Breast Neoplasms,
pubmed-meshheading:18835181-Cell Adhesion,
pubmed-meshheading:18835181-Cell Movement,
pubmed-meshheading:18835181-Cell Proliferation,
pubmed-meshheading:18835181-Computer Simulation,
pubmed-meshheading:18835181-Enzyme Inhibitors,
pubmed-meshheading:18835181-Female,
pubmed-meshheading:18835181-Focal Adhesion Protein-Tyrosine Kinases,
pubmed-meshheading:18835181-Humans,
pubmed-meshheading:18835181-Indole Alkaloids,
pubmed-meshheading:18835181-Indoles,
pubmed-meshheading:18835181-Phosphorylation,
pubmed-meshheading:18835181-Signal Transduction,
pubmed-meshheading:18835181-Tumor Cells, Cultured,
pubmed-meshheading:18835181-Wound Healing
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pubmed:year |
2008
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pubmed:articleTitle |
Building skeletally diverse architectures on the Indoline Scaffold: the discovery of a chemical probe of focal adhesion kinase signaling networks.
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pubmed:affiliation |
Ontario Institute for Cancer Research, MaRS Centre, South Tower, 101 College Street, Toronto, Ont., Canada M5G0A3.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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