Linked Life Data

18758968

Source:http://linkedlifedata.com/resource/pubmed/id/18758968

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2009-5-5
pubmed:abstractText
Complex behaviors are affected by multiple interacting loci with individually small and environmentally sensitive effects. Understanding the genetic architecture of behavioral traits begins with identifying the genes regulating these traits, mapping the subset of genetically varying quantitative trait loci (QTLs) in natural populations, and pinpointing the molecular polymorphisms defining QTL alleles. Drosophila brings an impressive toolkit to the challenge of genetically dissecting complex traits: P transposable element mutagenesis to identify genes regulating these traits; artificial selection from natural populations to create extreme trait phenotypes; high resolution mapping to identify positional candidate genes corresponding to QTLs; linkage disequilibrium mapping to identify molecular polymorphism(s) that functionally define QTL alleles; and whole genome transcriptional profiling to postulate networks of interacting genes affecting complex traits. Studies in Drosophila have revealed large numbers of pleiotropic genes that interact epistatically to regulate behavioral traits, and that can have sex- and environment-specific effects. These observations offer valuable lessons for understanding the genetic basis of variation for complex behaviors in other organisms, including humans.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1573-6857
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
136
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
295-302
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
The genetic architecture of complex behaviors: lessons from Drosophila.
pubmed:affiliation
Department of Genetics and The Keck Center for Behavioral Biology, North Carolina State University, Campus Box 7614, Raleigh, NC 27695, USA. trudy_mackay@ncsu.edu
pubmed:publicationType
Journal Article, Research Support, N.I.H., Extramural