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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2008-9-16
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pubmed:abstractText |
Meiotic chromosome segregation occurs in Drosophila oocytes on an acentrosomal spindle, which raises interesting questions regarding spindle assembly and function. One is how to organize a bipolar spindle without microtubule organizing centers at the poles. Another question is how to orient the chromosomes without kinetochore capture of microtubules that grow from the poles. We have characterized the mei-38 gene in Drosophila and found it may be required for chromosome organization within the karyosome. Nondisjunction of homologous chromosomes occurs in mei-38 mutants primarily at the first meiotic division in females but not in males where centrosomes are present. Most meiotic spindles in mei-38 oocytes are bipolar but poorly organized, and the chromosomes appear disorganized at metaphase. mei-38 encodes a novel protein that is conserved in the Diptera and may be a member of a multigene family. Mei-38 was previously identified (as ssp1) due to a role in mitotic spindle assembly in a Drosophila cell line. MEI-38 protein localizes to a specific population of spindle microtubules, appearing to be excluded from the overlap of interpolar microtubules in the central spindle. We suggest MEI-38 is required for the stability of parallel microtubules, including the kinetochore microtubules.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0016-6731
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
180
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
61-72
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:18757915-Animals,
pubmed-meshheading:18757915-Cell Cycle Proteins,
pubmed-meshheading:18757915-Chromosome Segregation,
pubmed-meshheading:18757915-Chromosomes,
pubmed-meshheading:18757915-Crosses, Genetic,
pubmed-meshheading:18757915-Crossing Over, Genetic,
pubmed-meshheading:18757915-Drosophila,
pubmed-meshheading:18757915-Drosophila Proteins,
pubmed-meshheading:18757915-Female,
pubmed-meshheading:18757915-Genotype,
pubmed-meshheading:18757915-Kinetochores,
pubmed-meshheading:18757915-Male,
pubmed-meshheading:18757915-Metaphase,
pubmed-meshheading:18757915-Microtubules,
pubmed-meshheading:18757915-Mitotic Spindle Apparatus,
pubmed-meshheading:18757915-Transgenes
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pubmed:year |
2008
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pubmed:articleTitle |
mei-38 is required for chromosome segregation during meiosis in Drosophila females.
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pubmed:affiliation |
Waksman Institute and Department of Genetics, Rutgers University, Piscataway, New Jersey 08854, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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