Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2008-5-1
pubmed:abstractText
The aim of this study was to determine if a ketorolac tromethamine (KT) gel solution could be administered in vivo via phonophoretic transdermal delivery using pulsed ultrasound by examining its anti-hyperalgesic and anti-inflammatory effects in a rat carrageenan inflammation model. 1% carrageenan was injected into the plantar surface of the right hindpaw of a rat, and anti-hyperalgesic and anti-inflammatory effects of KT via phonophoretic transdermal delivery were examined. The changes in the mechanical and thermal hyperalgesia, nociceptive flexor reflex (NFR), as well as the swelling changes were determined. According to the anti-hyperagesia and anti-inflammation tests, which were used to determine the change in the pain threshold, NFR and swelling showed that the group given the phonophoretic transdermal delivery of KT exhibited significantly more noticeable anti-hyperalgesic and anti-inflammatory effects than those treated with the simple application of a KT gel. The transdermal application of KT gel using phonophoresis had significant anti-hyperalgesic and anti-inflammatory effects. These findings suggest that the transdermal administration of a KT gel using phonophoresis using pulsed ultrasound might be useful for treating acute inflammation and pain.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0253-6269
pubmed:author
pubmed:issnType
Print
pubmed:volume
31
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
511-7
pubmed:meshHeading
pubmed-meshheading:18449510-Administration, Cutaneous, pubmed-meshheading:18449510-Analgesics, pubmed-meshheading:18449510-Animals, pubmed-meshheading:18449510-Anti-Inflammatory Agents, pubmed-meshheading:18449510-Carrageenan, pubmed-meshheading:18449510-Disease Models, Animal, pubmed-meshheading:18449510-Edema, pubmed-meshheading:18449510-Gels, pubmed-meshheading:18449510-Hyperalgesia, pubmed-meshheading:18449510-Ketorolac Tromethamine, pubmed-meshheading:18449510-Male, pubmed-meshheading:18449510-Pain Measurement, pubmed-meshheading:18449510-Pain Threshold, pubmed-meshheading:18449510-Phonophoresis, pubmed-meshheading:18449510-Rats, pubmed-meshheading:18449510-Rats, Sprague-Dawley, pubmed-meshheading:18449510-Reaction Time, pubmed-meshheading:18449510-Reflex, pubmed-meshheading:18449510-Time Factors
pubmed:year
2008
pubmed:articleTitle
Anti-hyperalgesic and anti-inflammatory effects of ketorolac tromethamine gel using pulsed ultrasound in inflamed rats.
pubmed:affiliation
Department of Pharmacy, Woosuk University, Samrye, Korea.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't