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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0023690,
umls-concept:C0152060,
umls-concept:C0205154,
umls-concept:C0384648,
umls-concept:C0597357,
umls-concept:C0963088,
umls-concept:C1171362,
umls-concept:C1306235,
umls-concept:C1515670,
umls-concept:C1637379,
umls-concept:C2350466,
umls-concept:C2717992
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pubmed:issue |
8
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pubmed:dateCreated |
2008-4-8
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pubmed:abstractText |
Th17 cells require IL-6 and TGFbeta for lineage commitment and IL-23 for maintenance. Unexpectedly, naive IL-6(-/-) splenocytes stimulated with anti-CD3 and IL-23 produced normal amounts of IL-17 during the first 24 h of culture. These rapid IL-6-independent IL-17 producers were identified as predominantly DX5(+) TCRbeta(+) NKT cells, and a comparable response could be found using the invariant NKT-specific ligand alpha-galactosylceramide. Human NKT cells also produced IL-17. NKT cells constitutively expressed IL-23R and RORgammat. Ligation of either TCR or IL-23R triggered IL-17 production and both together had a synergistic effect, suggesting independent but convergent pathways. IL-17 production was not restricted to a particular subset of NKT cells but they were NK1.1 negative. Importantly, in vivo administration of alpha-galactosylceramide triggered a rapid IL-17 response in the spleen. These data suggest an important biological role for innate IL-17 production by NKT cells that is rapid and precedes the adaptive IL-17 response.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18390697-12023369,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18390697-14872510,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18390697-15039760,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18390697-15657292,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18390697-16648837,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18390697-16648838,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18390697-16688182,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18390697-17150027,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18390697-17470641,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18390697-17581537,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18390697-17581588,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18390697-9020080,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18390697-9374462
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-17,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-23,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Receptor Subfamily 1...,
http://linkedlifedata.com/resource/pubmed/chemical/RORC protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Retinoic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Thyroid Hormone,
http://linkedlifedata.com/resource/pubmed/chemical/Rorc protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/interleukin-23 receptor, mouse
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
180
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5167-71
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pubmed:dateRevised |
2011-9-19
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pubmed:meshHeading |
pubmed-meshheading:18390697-Animals,
pubmed-meshheading:18390697-Cells, Cultured,
pubmed-meshheading:18390697-Humans,
pubmed-meshheading:18390697-Immunity, Innate,
pubmed-meshheading:18390697-Interleukin-17,
pubmed-meshheading:18390697-Interleukin-23,
pubmed-meshheading:18390697-Interleukin-6,
pubmed-meshheading:18390697-Mice,
pubmed-meshheading:18390697-Mice, Inbred C57BL,
pubmed-meshheading:18390697-Nuclear Receptor Subfamily 1, Group F, Member 3,
pubmed-meshheading:18390697-Receptors, Antigen, T-Cell,
pubmed-meshheading:18390697-Receptors, Interleukin,
pubmed-meshheading:18390697-Receptors, Retinoic Acid,
pubmed-meshheading:18390697-Receptors, Thyroid Hormone,
pubmed-meshheading:18390697-T-Lymphocyte Subsets
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pubmed:year |
2008
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pubmed:articleTitle |
Cutting edge: NKT cells constitutively express IL-23 receptor and RORgammat and rapidly produce IL-17 upon receptor ligation in an IL-6-independent fashion.
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pubmed:affiliation |
Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Intramural
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