Source:http://linkedlifedata.com/resource/pubmed/id/18337765
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
2008-6-11
|
| pubmed:abstractText |
Occurrence of phenotypic abnormalities in CD34(+) hematopoietic progenitor and precursor cells (HPC) and their major B-cell and nonlymphoid compartments has been frequently reported in myelodysplastic syndromes (MDS). Here, we analyze for the first time the numerical and phenotypic abnormalities of different maturation-associated subsets of bone marrow (BM) CD34(+) HPC from 50 newly diagnosed MDS patients in comparison to normal/reactive BM (n=29). Our results confirm the existence of heterogeneously altered phenotypes among CD34(+) HPC from MDS and indicate that such variability depends both on the relative distribution of the different subsets of CD34(+) HPC committed into the different myeloid and B-lymphoid compartments, and their immunophenotype (for example, higher reactivity for CD117 and CD13 and lower expression of CyMPO, CD64 and CD65 on CD34(+) immature and neutrophil precursors), a clear association existing between the accumulation of CD34(+) HPC and that of immature CD34(+) HPC. Interestingly, expansion of erythroid- and neutrophil-lineage CD34(+) cells is detected in low-grade MDS at the expense of CD34(+) plasmacytoid dendritic cell and B-cell precursors, while expansion of immature CD34(+) precursors occurs in high-grade MDS. On the basis of the number and severity of the phenotypic abnormalities detected, a scoring system is proposed that efficiently discriminates between normal/reactive and MDS CD34(+) HPC, the mean score significantly increasing from low- to high-grade MDS.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
1476-5551
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| pubmed:author |
pubmed-author:BárcenaPP,
pubmed-author:BarrenaSS,
pubmed-author:Fernandez-MosteirínNN,
pubmed-author:FernandezCC,
pubmed-author:FloresJJ,
pubmed-author:GiraltMM,
pubmed-author:Hernandez RivasJ MJM,
pubmed-author:Hernandez-CampoPP,
pubmed-author:JensenEE,
pubmed-author:LópezAA,
pubmed-author:MatarrazSS,
pubmed-author:OrfaoAA,
pubmed-author:PerdiguerLL,
pubmed-author:RasilloAA,
pubmed-author:SánchezM LML,
pubmed-author:SalvadorCC,
pubmed-author:SayaguesJ MJM
|
| pubmed:issnType |
Electronic
|
| pubmed:volume |
22
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1175-83
|
| pubmed:meshHeading |
pubmed-meshheading:18337765-Adult,
pubmed-meshheading:18337765-Aged,
pubmed-meshheading:18337765-Aged, 80 and over,
pubmed-meshheading:18337765-Antigens, CD34,
pubmed-meshheading:18337765-B-Lymphocytes,
pubmed-meshheading:18337765-Bone Marrow,
pubmed-meshheading:18337765-Cell Lineage,
pubmed-meshheading:18337765-Female,
pubmed-meshheading:18337765-Flow Cytometry,
pubmed-meshheading:18337765-Hematopoietic Stem Cells,
pubmed-meshheading:18337765-Humans,
pubmed-meshheading:18337765-Immunophenotyping,
pubmed-meshheading:18337765-In Situ Hybridization, Fluorescence,
pubmed-meshheading:18337765-Male,
pubmed-meshheading:18337765-Middle Aged,
pubmed-meshheading:18337765-Myelodysplastic Syndromes,
pubmed-meshheading:18337765-Myeloid Progenitor Cells,
pubmed-meshheading:18337765-Neutrophils,
pubmed-meshheading:18337765-Prognosis
|
| pubmed:year |
2008
|
| pubmed:articleTitle |
The immunophenotype of different immature, myeloid and B-cell lineage-committed CD34+ hematopoietic cells allows discrimination between normal/reactive and myelodysplastic syndrome precursors.
|
| pubmed:affiliation |
Servicio General de Citometría, Departamento de Medicina, Centro de Investigación del Cáncer, Instituto de Biología Molecular y Celular del Cáncer, CSIC-USAL, Universidad de Salamanca, Salamanca, Spain.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|