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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2008-3-3
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pubmed:abstractText |
In elderly patients oxybutynin (Sigma-Aldrich) is commonly used to treat overactive bladder despite increased prevalence of Alzheimer's disease in this population. We determined whether oxybutynin altered plaque formation, amyloid beta peptide expression and behavior in a transgenic mouse model of Alzheimer's disease expressing the mutant human presenilin 1 (deltaE9) and a chimeric mouse/human amyloid precursor protein (APPswe).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1527-3792
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
179
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1173-7
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:18206173-Alzheimer Disease,
pubmed-meshheading:18206173-Amyloid beta-Peptides,
pubmed-meshheading:18206173-Amyloid beta-Protein Precursor,
pubmed-meshheading:18206173-Animals,
pubmed-meshheading:18206173-Behavior,
pubmed-meshheading:18206173-Brain,
pubmed-meshheading:18206173-Chimera,
pubmed-meshheading:18206173-Disease Models, Animal,
pubmed-meshheading:18206173-Female,
pubmed-meshheading:18206173-Humans,
pubmed-meshheading:18206173-Male,
pubmed-meshheading:18206173-Mandelic Acids,
pubmed-meshheading:18206173-Mice,
pubmed-meshheading:18206173-Mice, Transgenic,
pubmed-meshheading:18206173-Muscarinic Antagonists,
pubmed-meshheading:18206173-Plaque, Amyloid,
pubmed-meshheading:18206173-Presenilin-1
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pubmed:year |
2008
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pubmed:articleTitle |
Does oxybutynin alter plaques, amyloid beta peptides and behavior in a mouse model of Alzheimer's disease?
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pubmed:affiliation |
Department of Neuroscience, University of Virginia Health System, Charlottesville, Virginia, USA. apklausner@vcu.edu
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pubmed:publicationType |
Journal Article
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