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| pubmed-article:18177722 | lifeskim:mentions | umls-concept:C0021641 | lld:lifeskim |
| pubmed-article:18177722 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:18177722 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:18177722 | lifeskim:mentions | umls-concept:C0013138 | lld:lifeskim |
| pubmed-article:18177722 | lifeskim:mentions | umls-concept:C1521739 | lld:lifeskim |
| pubmed-article:18177722 | lifeskim:mentions | umls-concept:C2587213 | lld:lifeskim |
| pubmed-article:18177722 | lifeskim:mentions | umls-concept:C1516240 | lld:lifeskim |
| pubmed-article:18177722 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:18177722 | pubmed:dateCreated | 2008-1-7 | lld:pubmed |
| pubmed-article:18177722 | pubmed:abstractText | Animals use the insulin/TOR signaling pathway to mediate their response to fluctuations in nutrient availability. Energy and amino acids are monitored at the single-cell level via the TOR branch of the pathway and systemically via insulin signaling to regulate cellular growth and metabolism. Using a combination of genetics, expression profiling, and chromatin immunoprecipitation, we examine nutritional control of gene expression and identify the transcription factor Myc as an important mediator of TOR-dependent regulation of ribosome biogenesis. We also identify myc as a direct target of FOXO and provide genetic evidence that Myc has a key role in mediating the effects of TOR and FOXO on growth and metabolism. FOXO and TOR also converge to regulate protein synthesis, acting via 4E-BP and Lk6, regulators of the translation factor eIF4E. This study uncovers a network of convergent regulation of protein biosynthesis by the FOXO and TOR branches of the nutrient-sensing pathway. | lld:pubmed |
| pubmed-article:18177722 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:18177722 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:18177722 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18177722 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:18177722 | pubmed:issn | 1550-4131 | lld:pubmed |
| pubmed-article:18177722 | pubmed:author | pubmed-author:CohenStephen... | lld:pubmed |
| pubmed-article:18177722 | pubmed:author | pubmed-author:HietakangasVi... | lld:pubmed |
| pubmed-article:18177722 | pubmed:author | pubmed-author:TelemanAureli... | lld:pubmed |
| pubmed-article:18177722 | pubmed:author | pubmed-author:SayadianAram... | lld:pubmed |
| pubmed-article:18177722 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:18177722 | pubmed:volume | 7 | lld:pubmed |
| pubmed-article:18177722 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18177722 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18177722 | pubmed:pagination | 21-32 | lld:pubmed |
| pubmed-article:18177722 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:18177722 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18177722 | pubmed:articleTitle | Nutritional control of protein biosynthetic capacity by insulin via Myc in Drosophila. | lld:pubmed |
| pubmed-article:18177722 | pubmed:affiliation | EMBL, Meyerhofstrasse 1, Heidelberg, Germany. | lld:pubmed |
| pubmed-article:18177722 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18177722 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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