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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2008-1-7
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pubmed:abstractText |
Animals use the insulin/TOR signaling pathway to mediate their response to fluctuations in nutrient availability. Energy and amino acids are monitored at the single-cell level via the TOR branch of the pathway and systemically via insulin signaling to regulate cellular growth and metabolism. Using a combination of genetics, expression profiling, and chromatin immunoprecipitation, we examine nutritional control of gene expression and identify the transcription factor Myc as an important mediator of TOR-dependent regulation of ribosome biogenesis. We also identify myc as a direct target of FOXO and provide genetic evidence that Myc has a key role in mediating the effects of TOR and FOXO on growth and metabolism. FOXO and TOR also converge to regulate protein synthesis, acting via 4E-BP and Lk6, regulators of the translation factor eIF4E. This study uncovers a network of convergent regulation of protein biosynthesis by the FOXO and TOR branches of the nutrient-sensing pathway.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Drosophila Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Eukaryotic Initiation Factor-4E,
http://linkedlifedata.com/resource/pubmed/chemical/FOXO protein, Drosophila,
http://linkedlifedata.com/resource/pubmed/chemical/Forkhead Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Lk6 protein, Drosophila,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase...,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphatidylinositol 3-Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-myc,
http://linkedlifedata.com/resource/pubmed/chemical/target of rapamycin protein...
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1550-4131
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
21-32
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:18177722-Animals,
pubmed-meshheading:18177722-Animals, Genetically Modified,
pubmed-meshheading:18177722-Cells, Cultured,
pubmed-meshheading:18177722-Drosophila,
pubmed-meshheading:18177722-Drosophila Proteins,
pubmed-meshheading:18177722-Electrophoresis, Polyacrylamide Gel,
pubmed-meshheading:18177722-Eukaryotic Initiation Factor-4E,
pubmed-meshheading:18177722-Fasting,
pubmed-meshheading:18177722-Forkhead Transcription Factors,
pubmed-meshheading:18177722-Gene Expression Profiling,
pubmed-meshheading:18177722-Immunoblotting,
pubmed-meshheading:18177722-Immunoprecipitation,
pubmed-meshheading:18177722-Insulin,
pubmed-meshheading:18177722-Mitogen-Activated Protein Kinase Kinases,
pubmed-meshheading:18177722-Models, Biological,
pubmed-meshheading:18177722-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:18177722-Phosphatidylinositol 3-Kinases,
pubmed-meshheading:18177722-Protein Biosynthesis,
pubmed-meshheading:18177722-Protein Kinases,
pubmed-meshheading:18177722-Proto-Oncogene Proteins c-myc,
pubmed-meshheading:18177722-Signal Transduction,
pubmed-meshheading:18177722-Transcription, Genetic
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pubmed:year |
2008
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pubmed:articleTitle |
Nutritional control of protein biosynthetic capacity by insulin via Myc in Drosophila.
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pubmed:affiliation |
EMBL, Meyerhofstrasse 1, Heidelberg, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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