| pubmed-article:18074356 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18074356 | lifeskim:mentions | umls-concept:C0220847 | lld:lifeskim |
| pubmed-article:18074356 | lifeskim:mentions | umls-concept:C0020971 | lld:lifeskim |
| pubmed-article:18074356 | lifeskim:mentions | umls-concept:C0025919 | lld:lifeskim |
| pubmed-article:18074356 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:18074356 | lifeskim:mentions | umls-concept:C0314603 | lld:lifeskim |
| pubmed-article:18074356 | lifeskim:mentions | umls-concept:C1979898 | lld:lifeskim |
| pubmed-article:18074356 | lifeskim:mentions | umls-concept:C0598995 | lld:lifeskim |
| pubmed-article:18074356 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:18074356 | pubmed:dateCreated | 2008-1-2 | lld:pubmed |
| pubmed-article:18074356 | pubmed:abstractText | DNA immunization has been used to induce either humoral or cellular immune responses against many antigens, including hepatitis C virus (HCV). In addition, DNA immunizations can be enhanced or modulated at the nucleotide level. Genetic immunizations were examined in BALB/c mice through the use of plasmids and chimeric DNA constructs encoding HCV core proteins and hepatitis B virus (HBV) precore (preC) regions. Plasmids encoding the truncated HCV core induced potent humoral and cellular responses to HCV; pcDNA3.0A-C154 produced a stronger antibody response than pcDNA3.0A-C191 (P < 0.01) and pcDNA3.0A-C69 (P < 0.05). HBV preC enhanced the humoral and cellular immune responses of BALB/c mice to HCV; however, pcDNA3.0A-C69preC resulted in a weak cytotoxic T lymphocyte (CTL) response. In addition, the humoral and cellular immune responses to HCV of groups immunized with pcDNA3.0A-C154preC and pcDNA3.0A-C191preC plasmids were higher than those of groups immunized with pcDNA3.0A-C154 and pcDNA3.0A-C191. In vivo CTL responses verified that mice immunized with preC core fused DNAs showed significantly high specific lysis compared with mice immunized with HCV cores only (P < 0.01). In our study, pcDNA3.0A-C154preC led to the highest immune response among all DNA constructs. Conclusion: DNA that encodes truncated HCV core proteins may lead to increased immune responses in vivo, and these responses may be enhanced by HBV preC. | lld:pubmed |
| pubmed-article:18074356 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18074356 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18074356 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18074356 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18074356 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18074356 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18074356 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18074356 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18074356 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:18074356 | pubmed:issn | 1527-3350 | lld:pubmed |
| pubmed-article:18074356 | pubmed:author | pubmed-author:OmataMasaoM | lld:pubmed |
| pubmed-article:18074356 | pubmed:author | pubmed-author:LiWeidongW | lld:pubmed |
| pubmed-article:18074356 | pubmed:author | pubmed-author:WangYueY | lld:pubmed |
| pubmed-article:18074356 | pubmed:author | pubmed-author:TanWenjieW | lld:pubmed |
| pubmed-article:18074356 | pubmed:author | pubmed-author:BiShengliS | lld:pubmed |
| pubmed-article:18074356 | pubmed:author | pubmed-author:ZhangXinwenX | lld:pubmed |
| pubmed-article:18074356 | pubmed:author | pubmed-author:ChenJunyingJ | lld:pubmed |
| pubmed-article:18074356 | pubmed:author | pubmed-author:BianTaoT | lld:pubmed |
| pubmed-article:18074356 | pubmed:author | pubmed-author:YangHuijuanH | lld:pubmed |
| pubmed-article:18074356 | pubmed:author | pubmed-author:LiaoGuoyangG | lld:pubmed |
| pubmed-article:18074356 | pubmed:author | pubmed-author:ChangJinhaiJ | lld:pubmed |
| pubmed-article:18074356 | pubmed:author | pubmed-author:SunMingboM | lld:pubmed |
| pubmed-article:18074356 | pubmed:author | pubmed-author:JiangShudeS | lld:pubmed |
| pubmed-article:18074356 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18074356 | pubmed:volume | 47 | lld:pubmed |
| pubmed-article:18074356 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18074356 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18074356 | pubmed:pagination | 25-34 | lld:pubmed |
| pubmed-article:18074356 | pubmed:dateRevised | 2008-7-7 | lld:pubmed |
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| pubmed-article:18074356 | pubmed:meshHeading | pubmed-meshheading:18074356... | lld:pubmed |
| pubmed-article:18074356 | pubmed:meshHeading | pubmed-meshheading:18074356... | lld:pubmed |
| pubmed-article:18074356 | pubmed:meshHeading | pubmed-meshheading:18074356... | lld:pubmed |
| pubmed-article:18074356 | pubmed:meshHeading | pubmed-meshheading:18074356... | lld:pubmed |
| pubmed-article:18074356 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18074356 | pubmed:articleTitle | Hepatitis B virus precore protein augments genetic immunizations of the truncated hepatitis C virus core in BALB/c mice. | lld:pubmed |
| pubmed-article:18074356 | pubmed:affiliation | Department of Viral Immunology, Institute of Medical Biology, Chinese Academy of Medical Science and Peking Union Medical College, Yunnan Province, People's Republic of China. | lld:pubmed |
| pubmed-article:18074356 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18074356 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:944568 | entrezgene:pubmed | pubmed-article:18074356 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:18074356 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18074356 | lld:pubmed |
