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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2007-12-6
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pubmed:abstractText |
The Fc receptor for IgA and IgM (Fcalpha/muR) is of particular interest because it can bind antibodies of both IgM and IgA isotypes and thus may play a pivotal role in systemic and mucosal immunity. Using IgM and IgA ligands and newly generated Fcalpha/muR specific monoclonal antibodies we have defined biochemical features and cellular distribution of the human Fcalpha/muR. Both recombinant and native forms of human Fcalpha/muR are expressed on the cell surface as remarkably stable homodimeric transmembrane glycoproteins that can bind specifically polymeric IgM or IgA. The only human B cells to express Fcalpha/muR, albeit at very low levels, are found in the pre-germinal center subpopulation defined by the IgD+/CD38+ phenotype. Hence the expression pattern differs from that of the mouse wherein Fcalpha/muR is expressed by both circulating and resident B cell populations. Significantly, the predominant cell type expressing the Fcalpha/muR in humans is the follicular dendritic cell of germinal centers. The Fcalpha/muR may thus function in antigen presentation and B cell selection in the germinal center response.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0014-2980
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
37
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3540-50
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:18000956-Adult,
pubmed-meshheading:18000956-Animals,
pubmed-meshheading:18000956-Antibodies, Monoclonal,
pubmed-meshheading:18000956-B-Lymphocyte Subsets,
pubmed-meshheading:18000956-Bone Marrow Cells,
pubmed-meshheading:18000956-Cell Line, Tumor,
pubmed-meshheading:18000956-Dendritic Cells, Follicular,
pubmed-meshheading:18000956-Dimerization,
pubmed-meshheading:18000956-Gene Expression Regulation,
pubmed-meshheading:18000956-Germinal Center,
pubmed-meshheading:18000956-Humans,
pubmed-meshheading:18000956-Immunoglobulin A,
pubmed-meshheading:18000956-Immunoglobulin M,
pubmed-meshheading:18000956-Lymphoid Tissue,
pubmed-meshheading:18000956-Lymphoma, T-Cell,
pubmed-meshheading:18000956-Mice,
pubmed-meshheading:18000956-Organ Specificity,
pubmed-meshheading:18000956-Palatine Tonsil,
pubmed-meshheading:18000956-Plasmacytoma,
pubmed-meshheading:18000956-Precursor Cells, B-Lymphoid,
pubmed-meshheading:18000956-Receptors, Fc,
pubmed-meshheading:18000956-Recombinant Fusion Proteins,
pubmed-meshheading:18000956-Spleen
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pubmed:year |
2007
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pubmed:articleTitle |
Unusual biochemical features and follicular dendritic cell expression of human Fcalpha/mu receptor.
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pubmed:affiliation |
Department of Pathology, University of Alabama at Birmingham, Birmingham 35294-2182, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, N.I.H., Extramural
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